This disclosure describes systems, methods, and devices related to scrambler initialization for multi-user (MU) clear to send (CTS) transmission. A first device may identify a MU request to send (RTS) frame received from a second device. The first device may determine an initial state of a scrambler based on the first 7 bits of a service field of the MU-RTS frame. The first device may cause first data to be scrambled, using the initial state of the scrambler, resulting in second data. The first device may cause to send a MU-CTS frame that comprises the second data to the second device.