A computer-implemented method for clinical decision support is provided according to an embodiment of the present disclosure. In the method, patient information can be obtained that comprises at least one clinical condition. A graph can be searched for at least one rule matching the at least one clinical condition. The graph represents a plurality of rule sets. The rule set comprises one or more rule. The rule can be indicated with a path comprising at least one first node and a second node. The first node can indicate a clinical condition, and the second node can indicate a clinical conclusion. Then, a clinical conclusion can be determined based on the at least one path in response that the at least one path matching the at least one clinical condition is searched out.