Systems and techniques for generating and/or employing a medical imaging stroke model are presented. In one example, a system employs a convolutional neural network to generate output data regarding a brain anatomical region based on diffusion-weighted imaging (DWI) data associated with the brain anatomical region and apparent diffusion coefficient (ADC) data associated with the brain anatomical region. The system also detects presence or absence of a medical stroke condition associated with the brain anatomical region based on the output data.