Invention Grant
- Patent Title: Benzisoxazole compound
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Application No.: US17050070Application Date: 2019-04-26
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Publication No.: US11548882B2Publication Date: 2023-01-10
- Inventor: Ryu Nagata , Yasuo Mori , Masayuki Mori , Motohiro Nishida , Takuro Tomita
- Applicant: OSAKA UNIVERSITY , KYOTO UNIVERSITY , Inter-University Research Institute Corporation National Institutes of Natural Sciences
- Applicant Address: JP Suita; JP Kyoto; JP Mitaka
- Assignee: OSAKA UNIVERSITY,KYOTO UNIVERSITY,Inter-University Research Institute Corporation National Institutes of Natural Sciences
- Current Assignee: OSAKA UNIVERSITY,KYOTO UNIVERSITY,Inter-University Research Institute Corporation National Institutes of Natural Sciences
- Current Assignee Address: JP Suita; JP Kyoto; JP Mitaka
- Agency: MH2 Technology Law Group, LLP
- Priority: JPJP2018-086929 20180427
- International Application: PCT/JP2019/018082 WO 20190426
- International Announcement: WO2019/208812 WO 20191031
- Main IPC: C07D413/12
- IPC: C07D413/12 ; A61P43/00 ; C07D261/20 ; C07D413/04 ; C07D413/14 ; C07D417/12 ; C07D487/08

Abstract:
The present invention provides a compound, a salt thereof, or a prodrug thereof as a compound effective for preventing and/or treating fibrosis, the compound being represented by formula (1) (wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom; of Y is a single or double bond when Y is a carbon atom, or of Y is a single bond when Y is a nitrogen atom; each R1 independently represents lower alkyl, or two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R1)p is oxo).
Public/Granted literature
- US20210238171A1 BENZISOXAZOLE COMPOUND Public/Granted day:2021-08-05
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