公开(公告)号：US20230138638A1

公开(公告)日：2023-05-04

申请号：US17965899

申请日：2022-10-14

申请人： Kyoto University ,  Shin-Etsu Chemical Co., Ltd.

发明人： Haruo KAWAMOTO ,  Eiji MINAMI ,  Yuanyuan ZHAO ,  Takashi NOMURA ,  Kazuto KOBAYASHI ,  Akiko MIKI

IPC分类号： C07C51/16 ,  C01B3/32 ,  B01J23/62 ,  B01J21/06

摘要： In a method for producing hydrogen and carboxylic acid, a primary alcohol of 1 to 7 carbon atoms and water are reacted by being continuously introduced into a flow reactor packed with a solid catalyst consisting of an alloy of ruthenium and tin on a support and passed through the reactor under temperature and pressure conditions at which the water assumes a gaseous state. This method enables hydrogen and carboxylic acid to be produced in a high yield or at a high purity from a primary alcohol and water in a short time and by simple operations.

公开(公告)号：US20230117374A1

公开(公告)日：2023-04-20

申请号：US17915751

申请日：2021-03-31

申请人： Kyoto University

发明人： Masatoshi Hagiwara ,  Akiko Kobayashi

IPC分类号： A61K31/429 ,  A61K31/4439 ,  A61P25/00

摘要： A pharmaceutical composition for suppressing neuro-inflammation; a pharmaceutical composition for assisting transplantation of neuron precursor cells, pluripotent stem cells, and/or neurons; a pharmaceutical composition for promoting the stabilization of Nrf2 protein in glial cells; a pharmaceutical composition for protecting nerve cells from neuro-inflammation are provided. Provided is a pharmaceutical composition containing, as an active ingredient, a compound having an inhibiting ability against phosphorylation activity of DYRK1A protein, or a pharmaceutically acceptable salt of the compound.

公开(公告)号：US20230112418A1

公开(公告)日：2023-04-13

申请号：US17904792

申请日：2021-03-04

申请人： NIHON MEDI-PHYSICS CO., LTD. ,  KYOTO UNIVERSITY

发明人： Yoshifumi MAYA ,  Masahiro ONO ,  Shimpei IIKUNI

IPC分类号： C07D487/04 ,  C07D513/04 ,  C07F5/00 ,  A61K51/04

摘要： In a compound of the present invention, in a macroscopic view of a chemical structure thereof, a chelating moiety is located at the center of the structure, an atomic group containing an albumin binding moiety binds to one side of the chelating moiety, and an atomic group containing a target molecule binding moiety binds to the other side of the chelating moiety. The chelating moiety is also preferably DOTA or a derivative thereof. The target molecule binding moiety preferably has a structure to bind to a target molecule expressed in a cancer tissue. The present invention also provides a radioactive labeled compound in which the compound is coordinated to a radioactive metal ion.

公开(公告)号：US20230098199A1

公开(公告)日：2023-03-30

申请号：US17801530

申请日：2020-09-29

申请人： Kyoto University ,  Daicel Corporation

发明人： Ken-ichi FUJITA ,  Takashi WATANABE ,  Naoko KOBAYASHI ,  Kenji KITAYAMA

IPC分类号： C01B3/22 ,  B01J31/22

摘要： Provided is a method of generating hydrogen efficiently using a renewable resource as a raw material.
A method of producing hydrogen according to the present disclosure is a method in which hydrogen is generated from a saccharide in the presence of a solvent and the following catalyst: catalyst which contains at least one metal element selected from the metal elements in Groups 8, 9, and 10. The catalyst is preferably a complex or salt of the metal element, and particularly preferably a complex including the at least one metal element selected from the metal elements in Groups 8, 9, and 10 and at least one ligand selected from pentamethylcyclopentadienyl, cyclopentadienyl, p-cymene, and 1,5-cyclooctadiene.
As the solvent, it is preferable to use at least one selected from an organic acid and an ionic liquid.
The saccharide may be a lignin-saccharide complex, and is preferably cellulose.

公开(公告)号：US20230067889A1

公开(公告)日：2023-03-02

申请号：US17797489

申请日：2021-02-26

申请人： KYOTO UNIVERSITY ,  SHIN-ETSU CHEMICAL CO., LTD.

发明人： Haruo KAWAMOTO ,  Eiji MINAMI ,  Takashi NOMURA ,  Hinano MIZUNO ,  Kazuto KOBAYASHI ,  Akiko MIKI

IPC分类号： C07H3/10 ,  C07H1/00 ,  C13K1/02

摘要： A method for producing a sugar anhydride, said method comprising: (1) a step for conducting a first heat treatment by heating a polysaccharide having a reducing end at 130-350° C. in the presence of an alcohol compound having 1-10 carbon atoms and not having an acetal structure; (2) a step for conducting a second heat treatment by heating the polysaccharide having been heated in the first heat treatment and thus thermally decomposing the polysaccharide to thereby give a gaseous sugar anhydride, without forming a char or with forming a filmy char, and without generating carbon monoxide or with regulating the generation amount of carbon monoxide, if any, to not more than 5 parts by mass per 100 parts by mass of the absolute dry mass of the polysaccharide; and (3) a collection step for cooling the gaseous sugar anhydride to a temperature equal to or lower than the boiling point thereof and then collecting the same. According to this method, a sugar anhydride can be easily produced at a high yield.

公开(公告)号：US20230067211A1

公开(公告)日：2023-03-02

申请号：US17799540

申请日：2020-12-22

申请人： TOYODA GOSEI CO., LTD. ,  KYOTO UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY

发明人： Hideki TAMAI ,  Takanori NAKAI ,  Hideyuki IMAI ,  Makoto ISHIDA ,  Tomoki OGOSHI ,  Koki MAEDA ,  Katsuto ONISHI ,  Tada-Aki YAMAGISHI ,  Takahiro KAKUTA ,  Masafumi YAGYU

IPC分类号： C08G65/26

摘要： A polyrotaxane of high heat resistance contains a linear molecule, a cyclic molecule enclosing the linear molecule such that the cyclic molecule is skewered with the linear molecule, and 5 blocking groups disposed at both ends of the linear molecule. The cyclic molecule contains an aromatic ring having, on a side chain, a phenolic hydroxyl group. The polyrotaxane can be produced by dissolving, in a methanol-containing solvent, a linear molecule and a cyclic 10 molecule containing an aromatic ring having, on a side chain, a phenolic hydroxyl group, to yield a pseudo polyrotaxane in which the cyclic molecule encloses the linear molecule such that the cyclic molecule is skewered with the linear molecule; and dissolving the pseudo polyrotaxane and a blocking group 15 material in a solvent, to dispose blocking groups at both ends of the linear molecule.

公开(公告)号：US20230051777A1

公开(公告)日：2023-02-16

申请号：US17794124

申请日：2021-02-18

申请人： SUMIDA CORPORATION ,  Kyoto University

发明人： Yoshiharu YOSHII ,  Masateru HASHIMOTO ,  Tsutomu OOTSUKA ,  Shingo HAMADA ,  Yuki TAKEMURA ,  Kan HAYASHI ,  Norikazu MIZUOCHI

IPC分类号： G01R33/24

摘要： A magnetic resonance member 1 includes a crystal structure and is capable of electron spin quantum operations with microwaves of different frequencies corresponding to arrangement orientations of a vacancy and an impurity in a crystal lattice. A magnetic field transmission unit 4 senses a measurement target magnetic field at plural measurement positions different from each other, and applies application magnetic fields corresponding to the measurement target magnetic field sensed at the plural measurement positions to the magnetic resonance member 1 along respective different directions corresponding to the aforementioned arrangement orientations. A measurement control unit 21 controls a high frequency power supply 12, and determines detection values detected by a detecting device (an irradiating device 5 and a light receiving device 6) of the physical phenomena corresponding to the plural measurement positions. A calculation unit 22 calculates the measurement target magnetic field at the plural measurement positions on the basis of the detection values.

公开(公告)号：US11578310B2

公开(公告)日：2023-02-14

申请号：US16312789

申请日：2017-06-21

申请人： Kyoto University

发明人： Shin Kaneko ,  Yutaka Yasui ,  Shoichi Iriguchi ,  Tatsuki Ueda

IPC分类号： C12N5/074 ,  C07D401/04 ,  C07K14/725 ,  C12N5/0783 ,  C12N5/10 ,  C12N15/85

摘要： A method for producing CD4/CD8 double-positive T cells, comprising the steps of: (1) culturing pluripotent stem cells in a medium to induce hematopoietic progenitor cells; and (2) culturing the hematopoietic progenitor cells obtained in the step (1) in a medium containing a p38 inhibitor and/or SDF-1 to induce CD4/CD8 double-positive T cells.

公开(公告)号：US11567080B2

公开(公告)日：2023-01-31

申请号：US16066111

申请日：2017-01-06

申请人： Kyoto University ,  KM BIOLOGICS CO., LTD.

发明人： Koichiro Hata ,  Shinji Uemoto ,  Hirofumi Hirao ,  Toyonari Kubota

IPC分类号： G01N33/573 ,  A61K38/48 ,  G01N33/576

摘要： New use of ADAMTS13 in the clinical filed is provided. The use of ADAMTS13 as a biomarker for monitoring the onset of liver damage, hepatic ischemia/reperfusion injury or the liver function after liver transplantation: a method of testing liver damage, a method of testing hepatic ischemia/reperfusion injury, or a method of testing the liver function after liver transplantation, each of the methods comprising measuring or monitoring the ADAMTS13 activity in a sample from a mammal; an agent for treating diseases selected from the group consisting of liver damage, hepatic ischemia/reperfusion injury and hepatic dysfunction after liver transplantation, which comprises ADAMTS13 or a mutant of ADAMTS13 as an effective ingredient.

公开(公告)号：US11559548B2

公开(公告)日：2023-01-24

申请号：US16494265

申请日：2018-03-13

申请人： KYOTO UNIVERSITY

发明人： Shin Kaneko ,  Norihiro Ueda ,  Yasushi Uemura ,  Kyoko Fukuda

IPC分类号： A61K35/17 ,  C12N5/0789 ,  C12N15/86 ,  C12N15/90

摘要： A method of producing helper T cells, comprising: (i) culturing T cells, which have been induced from pluripotent stem cells and into which a CD4 gene or a gene product thereof has been introduced, in a medium containing IL-2 and IL-15; and (ii) isolating CD40L-highly expressing T cells from cells obtained in step (i).