发明授权
- 专利标题： Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection
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申请号： US16629882申请日： 2018-07-11
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公开(公告)号： US11548893B2公开(公告)日： 2023-01-10
- 发明人: Michael Bruno Plewe , Kenneth McCormack , Gregory Henkel , Nadezda V. Sokolova , Eric Brown , Vidyasagar Reddy Gantla
- 申请人： Arisan Therapeutics, Inc.
- 申请人地址： US CA San Diego
- 专利权人： Arisan Therapeutics, Inc.
- 当前专利权人： Arisan Therapeutics, Inc.
- 当前专利权人地址： US CA San Diego
- 代理商 Karl Neidert
- 国际申请： PCT/US2018/041715 WO 20180711
- 国际公布： WO2019/018185 WO 20190124
- 主分类号： C07D471/10
- IPC分类号： C07D471/10 ; C07D471/08 ; C07D205/12 ; C07D209/54 ; C07D211/58 ; C07D295/192 ; C07D487/04 ; A61K45/06 ; A61K31/015 ; A61K31/13 ; A61K31/165 ; A61K31/397 ; A61K31/445 ; A61K31/4468 ; A61K31/496 ; A61K31/4965 ; A61K31/53 ; A61K31/7056 ; C07C235/40 ; C07C243/08 ; C07C211/56 ; C07C233/62
摘要：
The compounds of the invention as shown by general structure I, as shown below, are effective in treating filovirus infections. X is selected from the group consisting of O and H; R1 is selected from (C6 to C10) aryl and (C2 to C9) heteroaryl, and R2 is selected from (C1 to C10) alkyl, (C1 to C10) alkenyl, (C1 to C10) alkynyl, (C3 to C10) cycloalkyl, and (C5 to C10) cycloalkenyl, and NR3aR3b is defined in the specification. These compounds are effective in treating filovirii infections including Ebolavirus and Marburg virus.
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