- 专利标题： Bridged bicyclic inhibitors of menin-MLL and methods of use
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申请号： US16927844申请日： 2020-07-13
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公开(公告)号： US11555041B2公开(公告)日： 2023-01-17
- 发明人: Tao Wu , Liansheng Li , Yi Wang , Pingda Ren , Jolanta Grembecka , Tomasz Cierpicki , Szymon Klossowski , Jonathan Pollock , Dmitry Borkin
- 申请人： Kura Oncology, Inc. , The Regents of The University of Michigan
- 申请人地址： US CA San Diego; US MI Ann Arbor
- 专利权人： Kura Oncology, Inc.,The Regents of The University of Michigan
- 当前专利权人： Kura Oncology, Inc.,The Regents of The University of Michigan
- 当前专利权人地址： US CA San Diego; US MI Ann Arbor
- 代理机构： Wilson Sonsini Goodrich & Rosati
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; A61K31/445 ; A61P35/02
摘要：
The present disclosure provides compounds of Formula (I-A) for inhibiting the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The compounds are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin.
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