In embodiments of the present disclosure, there is provided a solution for managing a USB connection between a USB device and a host device. According to embodiments of the present disclosure, a USB management server receives, from a USB management client at a host device, USB ID information for identifying a USB device that is plugged into the host device. Whether the USB ID information is valid is determined based on an authentication policy for authenticating the USB device. If the USB ID information is valid, the USB management client is instructed to permit a connection between the USB device and the host device. Accordingly, the connection may be managed by the USB management server. Embodiments of the present disclosure present an effective way for managing USB connections in a centralized way, which provides various flexible authentication policies and requires less manual operations.