- 专利标题: 5-heteroaryl-1H-pyrazol-3-amine derivative
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申请号: US17731163申请日: 2022-04-27
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公开(公告)号: US11564920B2公开(公告)日: 2023-01-31
- 发明人: Seiji Kamioka , Hitoshi Ban , Makoto Matsuoka , Wataru Hirose , Naoaki Shimada , Kento Hayashi , Hiroki Umehara
- 申请人: Sumitomo Pharma Co., Ltd.
- 申请人地址: JP Osaka
- 专利权人: Sumitomo Pharma Co., Ltd.
- 当前专利权人: Sumitomo Pharma Co., Ltd.
- 当前专利权人地址: JP Osaka
- 代理机构: Oblon, McClelland, Maier & Neustadt, L.L.P.
- 优先权: JP2020-198648 20201130
- 主分类号: A61K31/497
- IPC分类号: A61K31/497 ; A61K31/506 ; A61K31/513 ; A61K31/519 ; A61K31/704 ; A61K31/7068 ; A61K31/7048 ; A61K31/4745 ; A61K31/282 ; A61K31/337 ; A61K31/454 ; A61K31/5377 ; A61K39/395 ; A61K47/24 ; A61K47/28 ; A61K9/127 ; A61K33/243 ; A61P35/00
摘要:
The present disclosure provides a compound that exerts an anticancer action based on CHK1 inhibition. The present disclosure was completed by finding that a compound represented by formula (1) or a pharmaceutically acceptable salt thereof exhibits an excellent antitumor action by having a potent inhibitory action against CHK1: wherein R1, R2, L, V, W, and Q are as defined herein, X, Y, and Z each independently represent CR8 or a nitrogen atom, wherein X, Y, and Z are not simultaneously CR8, and R8 is as defined herein.
公开/授权文献
- US20220273649A1 5-HETEROARYL-1H-PYRAZOL-3-AMINE DERIVATIVE 公开/授权日:2022-09-01
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