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公开(公告)号:US11564920B2
公开(公告)日:2023-01-31
申请号:US17731163
申请日:2022-04-27
发明人: Seiji Kamioka , Hitoshi Ban , Makoto Matsuoka , Wataru Hirose , Naoaki Shimada , Kento Hayashi , Hiroki Umehara
IPC分类号: A61K31/497 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/704 , A61K31/7068 , A61K31/7048 , A61K31/4745 , A61K31/282 , A61K31/337 , A61K31/454 , A61K31/5377 , A61K39/395 , A61K47/24 , A61K47/28 , A61K9/127 , A61K33/243 , A61P35/00
摘要: The present disclosure provides a compound that exerts an anticancer action based on CHK1 inhibition. The present disclosure was completed by finding that a compound represented by formula (1) or a pharmaceutically acceptable salt thereof exhibits an excellent antitumor action by having a potent inhibitory action against CHK1: wherein R1, R2, L, V, W, and Q are as defined herein, X, Y, and Z each independently represent CR8 or a nitrogen atom, wherein X, Y, and Z are not simultaneously CR8, and R8 is as defined herein.