- 专利标题： Genetically encoded calcium indicators and methods of use
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申请号： US16198166申请日： 2018-11-21
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公开(公告)号： US11572401B2公开(公告)日： 2023-02-07
- 发明人: Douglas Kim , Karel Svoboda , Loren Looger , Eric Schreiter
- 申请人： Howard Hughes Medical Institute
- 申请人地址： US MD Chevy Chase
- 专利权人： Howard Hughes Medical Institute
- 当前专利权人： Howard Hughes Medical Institute
- 当前专利权人地址： US MD Chevy Chase
- 代理机构： Fish & Richardson P.C.
- 主分类号： C07K14/72
- IPC分类号： C07K14/72 ; A61K38/00 ; C12N15/85 ; G01N33/50
摘要：
Genetically encoded calcium indicator (GECI) polypeptides and the nucleic acid molecules encoding such polypeptides are provided. In addition, methods of using such nucleic acids and polypeptides in methods of screening for agonists or antagonists of G-protein coupled receptor (GPCR) or ion channels and methods of monitoring neural activity also are provided.
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