- 专利标题： Hematopoietic stem and progenitor cells derived from hemogenic endothelial cells by episomal plasmid gene transfer
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申请号： US16620938申请日： 2018-06-14
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公开(公告)号： US11572544B2公开(公告)日： 2023-02-07
- 发明人: George Q. Daley
- 申请人： THE CHILDREN'S MEDICAL CENTER CORPORATION
- 申请人地址： US MA Boston
- 专利权人： THE CHILDREN'S MEDICAL CENTER CORPORATION
- 当前专利权人： THE CHILDREN'S MEDICAL CENTER CORPORATION
- 当前专利权人地址： US MA Boston
- 代理机构： Nixon Peabody LLP
- 代理商 David S. Resnick; Jeanne Jodoin
- 国际申请： PCT/US2018/037485 WO 20180614
- 国际公布： WO2018/232079 WO 20181220
- 主分类号： A61K35/28
- IPC分类号： A61K35/28 ; C12N5/0789
摘要：
Embodiments herein relate to in vitro production methods of hematopoietic stem cell (HSC) and hematopoietic stem and progenitor cell (HSPC) that have long-term multilineage hematopoiesis potentials upon in vivo engraftment. The HSC and HSPCs are derived from pluripotent stem cells-derived hemogenic endothelia cells (HE) by non-integrative episomal vectors-based gene transfer.
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