The present disclosure provides a system and a method for generating an imaging report. The method may include obtaining first imaging information and second imaging information. The first and second imaging information may be acquired from an examination region of a subject using a first imaging device or a second imaging device, respectively. The method may include identifying at least one first target ROI based on the first imaging information, and determining first reporting information corresponding to the at least one first target ROI. The method may include identifying at least one second target ROI with respect to the second imaging information based on the at least one first target ROI, and determining second reporting information corresponding to the at least one second target ROI. The method may further include generating a report based on at least a part of the first reporting information or the second reporting information.