A packaging structure, a packaging method, and a display apparatus are disclosed. The packaging structure includes: a first substrate and a second substrate opposite to each other; a plurality of first sealing frames located between the first substrate and the second substrate, wherein the first substrate, the second substrate and the plurality of first sealing frames enclose a plurality of sealed cavities not communicating with each other, and each of the sealed cavities is configured to package at least one to-be-packaged unit of a to-be-packaged device; and a first filler located in the sealed cavity.