- 专利标题: Peptidyl inhibitors of calcineurin-NFAT interaction
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申请号: US16965718申请日: 2019-01-29
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公开(公告)号: US11576946B2公开(公告)日: 2023-02-14
- 发明人: Dehua Pei , John W. Christman , Manjula Karpurapu , Patrick G. Dougherty
- 申请人: Ohio State Innovation Foundation
- 申请人地址: US OH Columbus
- 专利权人: Ohio State Innovation Foundation
- 当前专利权人: Ohio State Innovation Foundation
- 当前专利权人地址: US OH Columbus
- 代理机构: Meunier Carlin & Curfman LLC
- 国际申请: PCT/US2019/015695 WO 20190129
- 国际公布: WO2019/148194 WO 20190801
- 主分类号: A61K38/08
- IPC分类号: A61K38/08 ; A61K47/64 ; A61P11/00
摘要:
Described are peptides and peptide conjugates comprising CN binding motifs (CNBM) which inhibit the CN-NFAT interaction. In some embodiments, the peptides comprise: (i) CNBM; (ii) a hydrophobic, non-peptidic moiety (RH) which interacts with the hydrophobic pocket on a CN protein; (iii) a sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-, wherein each of AAU2, AAU3, AAU4, AAU5, and AAU6, is, independently, optional, and each of AAU1, AAU2, AAU3, AAU4, AAU5, and AAU6 when present is independently an amino acid as defined herein; or (iv) combinations thereof. In some embodiments, RH is conjugated to the N- or C-terminus of the CNBM. In some embodiments, the sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6- is conjugated to the N- or C terminus of the CNBM. In some embodiments, the peptides comprise: CNBM and RH. In some embodiments. In some embodiments, the peptides comprise: CNBM and AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-. In some embodiments, the peptides of the disclosure CNBM and RH.
公开/授权文献
- US20210169966A1 PEPTIDYL INHIBITORS OF CALCINEURIN-NFAT INTERACTION 公开/授权日:2021-06-10