Invention Grant
- Patent Title: Polycrystalline form of dehydrophenylahistin-like compound, and manufacturing and purification method and application thereof
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Application No.: US16995045Application Date: 2020-08-17
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Publication No.: US11578057B2Publication Date: 2023-02-14
- Inventor: Wenbao Li , Shixiao Wang , Zhongpeng Ding , Yingwei Hou , Huashi Guan
- Applicant: Shenzhen Huahong Marine Biomedicine Co., Ltd.
- Applicant Address: CN Shenzhen
- Assignee: Shenzhen Huahong Marine Biomedicine Co., Ltd.
- Current Assignee: Shenzhen Huahong Marine Biomedicine Co., Ltd.
- Current Assignee Address: CN Shenzhen
- Agency: Michael Best & Friedrich LLP
- Priority: CN201610664088.6 20160812,CN201610664196.3 20160812,CN201610665377.8 20160812
- Main IPC: C07D403/06
- IPC: C07D403/06 ; A61P35/00 ; A61K31/496 ; A61P31/10

Abstract:
A polycrystalline form of a dehydrophenylahistin-like compound, and a manufacturing and purification method and application thereof. A (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)deuteromethylene]piperazine-2,5-dione monohydrate crystal and a (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylene]piperazine-2,5-dione monohydrate crystal are more competitive crystalline forms with stable quality. The manufacturing and purification method is simple and easy to operate, and can effectively control the generation of a trans-isomer contaminant to obtain a high purity product. The polycrystalline form of the dehydrophenylahistin-like compound has a certain value in an application for manufacturing an antitumor pharmaceutical product.
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