- Patent Title: Production of arylpyrrol compounds in the presence of DIPEA base
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Application No.: US16492119Application Date: 2018-03-05
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Publication No.: US11584716B2Publication Date: 2023-02-21
- Inventor: David A. Cortes , Ryan Michael Phillips
- Applicant: BASF Agro B.V.
- Applicant Address: NL Arnhem
- Assignee: BASF Agro B.V.
- Current Assignee: BASF Agro B.V.
- Current Assignee Address: NL Arnhem
- Agency: Marshall, Gerstein & Borun LLP
- Priority: EP17160466 20170313
- International Application: PCT/EP2018/055261 WO 20180305
- International Announcement: WO2018/166819 WO 20180920
- Main IPC: C07D207/34
- IPC: C07D207/34 ; C07D207/337

Abstract:
A process A for the production of compounds of formula I is provided. Process A includes Step A of reacting compounds of formula II with 2,3-dihalopropionitrile or 2-haloacrylonitrile in the presence of DIPEA. A process B for the production of compounds of formula III is also provided. Process B includes Step B of reacting compounds of formula I with Br2 in the presence of DIPEA. A process C for the production of compounds of formula IV is further provided. Process C includes Step C of reacting compounds of formula III with di(C1-C4-alkoxy)methane and either POCl3, or a mixture comprising POCl3 and DMF, in the presence of DIPEA. Additionally, the use of DIPEA as a base in the production of compounds of formula I, compounds of formula III, or compounds of formula IV is provided.
Public/Granted literature
- US20210139422A1 PRODUCTION OF ARYLPYRROL COMPOUNDS IN THE PRESENCE OF DIPEA BASE Public/Granted day:2021-05-13
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