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公开(公告)号:US20220193041A1
公开(公告)日:2022-06-23
申请号:US17601114
申请日:2020-04-01
发明人: Jae Young CHOI , Gyoonhee HAN , Wan NAMKUNG , Sung Ha PARK , Moo Suk PARK
IPC分类号: A61K31/422 , A61K9/00 , A61P11/06 , C07D413/06 , C07D417/06 , C07D263/42 , C07D413/14 , C07D413/04 , C07D495/04 , C07D413/10 , C07D413/12 , C07D207/337 , C07D333/24 , C07D307/54 , C07D277/30 , C07D231/12 , C07D333/60 , C07D209/20 , A61K31/427 , A61K31/4709 , A61K31/4439 , A61K31/421 , A61K31/454 , A61K31/519 , A61K31/40 , A61K31/381 , A61K31/341 , A61K31/426 , A61K31/415
摘要: The present invention relates to a novel compound, and a composition for preventing or treating of respiratory disease comprising the novel compound, E- or Z-isomer thereof, optical isomer thereof, a mixture of two isomers thereof, precursor thereof, pharmaceutically acceptable salt thereof or solvate thereof as an active ingredient.
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公开(公告)号:US20210147415A1
公开(公告)日:2021-05-20
申请号:US17091247
申请日:2020-11-06
IPC分类号: C07D471/04 , C07D317/60 , C07D235/28 , C07D493/04 , C07D207/337 , C07D209/42 , C07D307/68 , C07C59/70 , C07C59/68 , C07D239/22 , G01N27/447 , G01N33/50
摘要: The invention relates to inhibitors of the NHR2 tetramerization and their use as tumor therapeutics (e.g. against acute myeloid leukemia (AML)), cytostatics, and diagnostic agents.
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公开(公告)号:US10975054B2
公开(公告)日:2021-04-13
申请号:US16593776
申请日:2019-10-04
发明人: Gary A. Piazza , Xi Chen , Adam B. Keeton , Michael R. Boyd
IPC分类号: C07D317/64 , A61K31/445 , A61K31/44 , A61K31/40 , A61K31/401 , A61K31/36 , A61K31/341 , C07D211/56 , C07D213/75 , C07D207/14 , C07D207/337 , C07D307/54 , C07C235/32 , C07C237/20 , C07D235/30 , C07D405/12 , C07D213/24 , C07D307/38 , C07D307/52 , A61K45/06 , C07C233/58
摘要: Disclosed are compounds, for example, compounds of formula I, wherein R, R0, R1-R8, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.
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公开(公告)号:US10717722B2
公开(公告)日:2020-07-21
申请号:US16446360
申请日:2019-06-19
发明人: Anne-Marie Beausoleil , Ryan Hudson
IPC分类号: C07D207/337 , C07D401/12 , C07D401/10 , C07D403/10 , A61P9/10 , A61P35/00 , A61P27/00 , C07D401/14
摘要: The aryl sulfonamide compounds of this invention have powerful and cell-type specific Bcl inhibitory activity. Compounds of this invention include compounds according to formula (I): Selected compounds in this class promote apoptosis in senescent cells, and are being developed for treating senescent-related conditions. Selected compounds in this class promote apoptosis in cancer cells, and can be developed as chemotherapeutic agents.
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公开(公告)号:US20200223815A1
公开(公告)日:2020-07-16
申请号:US16834267
申请日:2020-03-30
发明人: Gary A. Piazza , Xi Chen , Adam B. Keeton , Michael R. Boyd
IPC分类号: C07D317/64 , A61K31/445 , A61K31/44 , A61K31/40 , A61K31/401 , A61K31/36 , A61K31/341 , C07D211/56 , C07D213/75 , C07D207/14 , C07D207/337 , C07D307/54 , C07C235/32 , C07C237/20 , C07D235/30 , C07D405/12 , C07D213/24 , C07D307/38 , C07D307/52 , A61K45/06 , C07C233/58
摘要: Disclosed are compounds, for example, compounds of formula I, wherein R, R0, R1-R8, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.
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公开(公告)号:US10668051B2
公开(公告)日:2020-06-02
申请号:US16248528
申请日:2019-01-15
发明人: Meyyappan Muthuppalaniappan , Srikant Viswanadha , Gayatri S. Merikapudi , Swaroop K. Vakkalanka
IPC分类号: A61K31/433 , A61K31/427 , A61K31/415 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61P29/00 , A61K31/444 , A61K31/506 , C07D231/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D207/327 , C07D401/10 , C07D403/10 , C07D413/10 , C07D417/10 , A61K31/422 , A61K31/455 , A61K45/06 , C07D207/337 , C07D295/195 , C12N5/078
摘要: Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present disclosure also relates to methods for treating non-small cell lung cancer (NSCLC) with CRAC inhibitors, and to methods for identifying therapeutics for treating and of diagnosing cancer.
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公开(公告)号:US10538489B2
公开(公告)日:2020-01-21
申请号:US16200178
申请日:2018-11-26
发明人: Tomomi Ikemoto , Naohiro Fukuda
IPC分类号: C07D207/337 , C07D207/333 , C07D207/34 , C07D207/36 , C07D401/12 , C07D207/30 , C07D207/48
摘要: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
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公开(公告)号:US20200009103A1
公开(公告)日:2020-01-09
申请号:US16415089
申请日:2019-05-17
申请人: Orion Corporation
发明人: Marko AHLMARK , David DIN BELLE , Mika KAUPPALA , Anne LUIRO , Taina PAJUNEN , Jamo PYSTYNEN , Eija TIAINEN , Matti VAISMAA , Josef MESSINGER
IPC分类号: A61K31/277 , C07C255/59 , C07C309/66 , C07C317/46 , C07C323/62 , C07C255/53 , C07C255/54 , C07C255/57 , C07D333/24 , C07C311/29 , C07D207/337 , C07D277/30 , C07D295/192 , C07D213/57 , C07D307/54 , C07D307/80 , C07D309/06 , C07D309/12 , C07D231/12 , C07D231/14 , C07D333/28 , C07D333/70 , C07D277/34 , C07D277/74 , C07D211/14 , C07D295/155 , C07D213/62 , C07D333/60 , A61K31/198 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/5377 , C07C323/29 , C07D307/81 , C07D309/22
摘要: Compounds of formula (I), wherein R1 is as defined in the claims, exhibit COMT enzyme inhibiting activity and are thus useful as COMT inhibitors. Methods of treatment and pharmaceutical dosage forms are also disclosed.
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公开(公告)号:US10246450B2
公开(公告)日:2019-04-02
申请号:US15892229
申请日:2018-02-08
发明人: Meyyappan Muthuppalaniappan , Srikant Viswanadha , Gayatri S. Merikapudi , Swaroop K. Vakkalanka
IPC分类号: C07D417/10 , A61K31/415 , A61K31/422 , A61K31/433 , A61K31/4439 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D207/327 , C07D207/337 , C07D231/12 , C07D295/195 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C12N5/078 , A61K31/427
摘要: Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present disclosure also relates to methods for treating non-small cell lung cancer (NSCLC) with CRAC inhibitors, and to methods for identifying therapeutics for treating and of diagnosing cancer.
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公开(公告)号:US10150737B2
公开(公告)日:2018-12-11
申请号:US15033464
申请日:2014-11-05
发明人: Werner Hallenbach , Hans-Georg Schwarz , Kerstin Ilg , Ulrich Goergens , Johannes Koebberling , Andreas Turberg , Niels Boehnke , Michael Maue , Robert Velten , Tobias Harschneck , Julia Johanna Hahn , Sebastian Horstmann
IPC分类号: A01N43/40 , A01N43/56 , A01N43/80 , C07D231/12 , C07D261/08 , C07D401/04 , C07D403/04 , C07D207/337 , C07D231/00 , C07D413/04 , C07D261/00 , A01N43/36 , A01N43/54
摘要: The invention relates inter alia to compounds of the general formula (I) in which the A1-A4, T, n, W, Q, R1 and B1-B4 radicals are each as defined in the description. Also described are processes for preparing the compounds of the formula (I). The inventive compounds are especially suitable for controlling insects, arachnids and nematodes in agriculture, and ectoparasites in veterinary medicine.
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