Invention Grant
- Patent Title: In situ determination of alum filling evenness and sedimentation in pharmaceutical products using water proton NMR
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Application No.: US16593145Application Date: 2019-10-04
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Publication No.: US11585770B2Publication Date: 2023-02-21
- Inventor: Yihua (Bruce) Yu , Marc Taraban , Christopher Fox
- Applicant: UNIVERSITY OF MARYLAND, BALTIMORE , ACCESS TO ADVANCED HEALTH INSTITUTE
- Applicant Address: US MD Baltimore; US WA Seattle
- Assignee: UNIVERSITY OF MARYLAND, BALTIMORE,ACCESS TO ADVANCED HEALTH INSTITUTE
- Current Assignee: UNIVERSITY OF MARYLAND, BALTIMORE,ACCESS TO ADVANCED HEALTH INSTITUTE
- Current Assignee Address: US MD Baltimore; US WA Seattle
- Agency: Casimir Jones SC
- Agent Tristan A. Fuierer
- Main IPC: G01N24/08
- IPC: G01N24/08 ; G01N33/15
Abstract:
A method of using the transverse relaxation rate (R2) of solvent NMR signal to noninvasively assess alum-containing products such as vaccines. This technique can be used for quality control in vaccine manufacturing (e.g., fill-finish step) to determine the evenness of alum filling level as well as extent of alum particle sedimentation in filled and sealed products.
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