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1.发明申请公开(公告)号：US20210388454A1
公开(公告)日：2021-12-16
申请号：US17325839
申请日：2021-05-20
IPC分类号： C12Q1/70
摘要： The present disclosure relates to a nanotechnology-based molecular sensing system, compositions, and methods that can be adapted to accurately detect a target gene in clinical samples, using anti-sense oligonucleotide capped plasmonic nanoparticles for selective detection of biological pathogens.
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2.发明公开公开(公告)号：US20240218458A1
公开(公告)日：2024-07-04
申请号：US18332359
申请日：2023-06-09
申请人： University of Maryland, Baltimore , University of Maryland, Baltimore County , The Penn State Research Foundation
发明人： Dipanjan Pan , Parikshit Moitra , Ketan Dighe
CPC分类号： C12Q1/689 , C12N9/22 , C12N15/11 , C12N2310/20
摘要： The present invention provides methods of detecting the presence or absence of nucleic acid from Chlamydia trachomatis and the presence or absence of nucleic acid from Neisseria gonorrhoeae in a sample from a subject using CRISPR nucleases and crRNAs specific for Chlamydia trachomatis and Neisseria gonorrhoeae nucleic acid, kits for carrying out the methods and methods of treating subjects infected with Chlamydia trachomatis and/or Neisseria gonorrhoeae.
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3.发明公开公开(公告)号：US20230323488A1
公开(公告)日：2023-10-12
申请号：US18298540
申请日：2023-04-11
发明人： Govind RAO , Xudong GE , Douglas D. FREY , Sai Sathish RAMAMURTHY , Dipanjan PAN
IPC分类号： C12Q1/70 , C12Q1/6844 , G01N33/569 , G01N1/40 , B01L3/00 , G01N33/543
CPC分类号： C12Q1/701 , C12Q1/6844 , G01N33/56983 , G01N1/40 , B01L3/502761 , G01N33/54386 , G01N2333/165 , B01L2200/0652 , B01L2200/16
摘要： The present invention relates to the use of a condensate collector such as portable or stationary dehumidifier placed in a defined testing space or area and used as a readily available and affordable tool to collect airborne virus particles in collected condensate from the testing atmosphere in the defined testing space or area, wherein the collected condensate is analyzed for virus biomarkers to identify viruses, such as SARS-CoV-2 or mutants or variants thereof, in the testing atmosphere.
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公开(公告)号：US20200222709A1
公开(公告)日：2020-07-16
申请号：US16739650
申请日：2020-01-10
发明人： L. Elliot Hong , Fow-Sen Choa , Qinglei Meng
IPC分类号： A61N2/02 , H01F7/20 , H01F27/28 , H01F27/255 , A61N2/00
摘要： Disclosed is an electromagnetic coil system for use during transcranial or transdermal stimulation procedures, in which an electrically conductive coil wraps around a magnetic core at an oblique wrapping angle to provide a more directed focal spot size at a given depth inside of, for example, a patient's body. In certain configurations, the electrically conductive coil may be adjustable with respect to the magnetic core, such that the wrapping angle of the electrically conductive coil may be modified to, in turn, adjust the focal spot size of the induced electric field generated by the system as may desired to concentrate the field at a particularly desired location.
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5.发明申请公开(公告)号：US20180193658A1
公开(公告)日：2018-07-12
申请号：US15740175
申请日：2016-06-29
发明人： Liyi Elliott HONG , Fow-Sen CHOA
摘要： Methods and systems to control magnetic fields and magnetic field induced currents, and to provide stimulations within a patient's body, e.g.: deep brain stimulation, in a non-invasive manner and with greater focus and control than has been afforded by prior known methods and systems. An array of magnetic coils is provided and positionable about a portion of a patient's body, and are configured to create a small region of a magnetic hole, or configured to create a small region of concentrated magnetic field strength, or their combination, and at depths within the patient's body in a focused region and sparing the surrounding tissues of the focused region, that have previously not been receptive to non-invasive TMS methods, which are either focused but can affect only the surface and shadow areas, or that can reach certain depths but by doing so only through affecting large surface areas and deep tissue areas.
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公开(公告)号：US20240001136A1
公开(公告)日：2024-01-04
申请号：US18345614
申请日：2023-06-30
发明人： Fow-Sen CHOA , L. Elliott Hong
CPC分类号： A61N2/02 , A61N2/006 , H01F27/2823
摘要： The present invention relates to angle-tuned (AT) ring coil devices to reduce the individual coil footprint and improve depth-spread characteristics of transcranial magnetic stimulation (TMS) systems. The AT coil device includes multiple stacked coils, which enhances field strength, reduces the footprint, and increases the field penetration depth by modifying its geometric distribution. Moreover, the AT coil devices demonstrated superior performance for multisite stimulation due to their smaller footprint, making them suitable for multisite stimulations of inter and intra-hemispheric brain regions with an improved spread and less electric field divergence.
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7.发明公开公开(公告)号：US20230152320A1
公开(公告)日：2023-05-18
申请号：US18055333
申请日：2022-11-14
IPC分类号： G01N33/569 , G01N29/12 , G01N29/24 , G01N33/543
CPC分类号： G01N33/56983 , G01N29/12 , G01N29/2443 , G01N33/54373 , G01N2291/014 , G01N2291/023 , G01N2333/165
摘要： An apparatus is provided for airborne pathogen detection, which includes a crystal microbalance. The apparatus includes specific capture probes that are affixed to the crystal microbalance and are designed to bind to and capture a specific pathogen, such as a virus particle. This capture causes a change in mass of the crystal microbalance that can be detected. A method is provided for airborne pathogen detection, which includes calibrating a resonant frequency of the crystal microbalance to a mass on the crystal microbalance. The method also includes a step of conjugating the antibody to the crystal microbalance. The method also includes, for each measurement time, measuring a resonant frequency of the crystal microbalance and determining a mass change due to binding of the pathogen to the detector. This mass change is then related to pathogen load in the medium. A notification is output if the viral load exceeds a predetermined threshold.
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8.发明申请公开(公告)号：US20200078300A1
公开(公告)日：2020-03-12
申请号：US16568396
申请日：2019-09-12
申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY , UNIVERSITY OF MARYLAND, BALTIMORE , NORTHWESTERN UNIVERSITY
发明人： GREGORY SZETO , EVAN SCOTT , AMIT GOLDING , MARILYN ALLEN , NICHOLAS B. KARABIN
IPC分类号： A61K9/127 , A61K31/4706 , A61P37/06 , A61K9/107 , A61K31/52 , A61K31/573
摘要： The present invention provides for delivery of therapeutic drug in a polymeric delivery system comprising a PEG-bl-PPS di-block polymer formed in a micelle, filomicelle, or polymersome structure, wherein the structure effectively binds and/or interacts through shape-based targeting with a targeted cell type.
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公开(公告)号：US10518098B2
公开(公告)日：2019-12-31
申请号：US15300979
申请日：2015-04-02
发明人： Liyi Elliott Hong , Fow-Sen Choa
摘要： The present invention discloses methods and systems to control magnetic fields and magnetic field induced currents, and more particularly to provide stimulations within a patient's body, such as deep brain stimulation, in a non-invasive manner and with greater focus and control than has been afforded by prior known methods and systems. In accordance with certain aspects of an embodiment, an array of magnetic coils is provided and positionable about a portion of a patient's body. During operation, at least some of the magnetic coils function as DC coil pairs configured to generate a DC magnetic field, while at least some DC coil of the other magnetic coils function as transient magnetic field generators to generate an induced current within a portion of the patient's body, such as in a region of the patient's brain. The system is configured such that the DC magnetic fields may be used to manipulate the transient magnetic fields, in turn allowing significantly improved control and focus of the induced current within a specifically desired volume of interest within a patient's body.
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公开(公告)号：US20230416851A1
公开(公告)日：2023-12-28
申请号：US18247474
申请日：2021-10-05
IPC分类号： C12Q1/70 , C12Q1/6825 , B01L3/00
CPC分类号： C12Q1/701 , C12Q1/6825 , B01L3/502715 , B01L2300/0663 , B01L2200/16
摘要： The present disclosure relates to electrochemical biosensing systems and methods that can be adapted to accurately and rapidly detect a target gene in clinical samples, using anti-sense oligonucleotides for selective detection of biological pathogens.
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