Systems and methods for statistical dynamic geofencing are discussed. For example, a method for statistical dynamic geofencing can include operations such as receiving a location-based campaign request, analyzing demographic data, determining a geofence parameter, generating a geofence, and distributing location-aware advertisements. The location-based campaign request can include a list of points of interest (POIs) and a target demographic parameter. The demographic data can include data from geographic areas surrounding at least a portion of the POIs as well as data related to the target demographic parameter. The geofence can be generated based at least in part on the geofence parameter, where the geofence parameter directly affects either the size or shape of the geofence. The location-aware advertisements are distributed to a plurality of mobile devices determined to be within the geofence.