- Patent Title: Specific sites for modifying antibodies to make immunoconjugates
-
Application No.: US16701576Application Date: 2019-12-03
-
Publication No.: US11596695B2Publication Date: 2023-03-07
- Inventor: Bernhard Hubert Geierstanger , Weijia Ou , Tetsuo Uno
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agency: K&L Gates LLP
- Main IPC: A61K47/68
- IPC: A61K47/68 ; C07K16/32 ; C07K16/28
Abstract:
The present invention provides specific sites for modifying antibodies or antibody fragments by replacing at least one native amino acid in the constant region of a parental antibody or antibody fragment with cysteine, which can be used as a site of attachment for a payload or linker-payload combination.
Public/Granted literature
- US20200338207A1 SPECIFIC SITES FOR MODIFYING ANTIBODIES TO MAKE IMMUNOCONJUGATES Public/Granted day:2020-10-29
Information query
IPC分类:
