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公开(公告)号：US20200164084A1
公开(公告)日：2020-05-28
申请号：US16608608
申请日：2018-04-27
Applicant: NOVARTIS AG
Inventor： Alex Cortez , Bernhard Hubert Geierstanger , Rodrigo Andreas Hess , Timothy Z. Hoffman , Shailaja Kasibhatla , Tetsuo Uno , Xing Wang , Tom Yao-Hsiang Wu
IPC: A61K47/68 , A61K39/395 , A61K9/00 , A61P35/00 , A61K31/519 , A61K39/00
Abstract: Provided herein are antibody conjugates comprising toll-like receptor agonists and the use of such conjugates for the treatment of cancer. In some embodiments, the conjugates comprise anti-HER2 antibodies. In some embodiments, the conjugates are used in combination with a second therapeutic agent.
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公开(公告)号：US10280139B2
公开(公告)日：2019-05-07
申请号：US15822930
申请日：2017-11-27
Applicant: NOVARTIS AG
Inventor： Bernhard Hubert Geierstanger , Jan Grunewald , Weijia Ou , Shifeng Pan , Tetsuo Uno , Yongqin Wan , Xing Wang
IPC: C07D207/09 , C07K5/02 , A61K47/68 , C07D401/12 , C07D403/12 , C07D403/14 , C07D413/12 , C07K16/32
Abstract: Disclosed herein are novel compounds of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
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公开(公告)号：US12180291B2
公开(公告)日：2024-12-31
申请号：US18164519
申请日：2023-02-03
Applicant: Novartis AG
Inventor： Steven Bender , Tracy Charlton , Anna Galkin , Bernhard Hubert Geierstanger , Scott Martin Glaser , Shailaja Kasibhatla , Mark Knuth , Sabine Rottmann , Sarah Rue , Glen Spraggon , Tetsuo Uno
Abstract: This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.
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公开(公告)号：US10787480B2
公开(公告)日：2020-09-29
申请号：US16439204
申请日：2019-06-12
Applicant: NOVARTIS AG
Inventor： Bernhard Hubert Geierstanger , Jan Grunewald , Yunho Jin , Weijia Ou , Tetsuo Uno , Yongqin Wan , Xing Wang
Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
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公开(公告)号：US20250064964A1
公开(公告)日：2025-02-27
申请号：US18937914
申请日：2024-11-05
Applicant: Novartis AG
Inventor： Anthony Edward Boitano , Matthew Burger , Susan E. Cellitti , Michael P. Cooke , Catrin Finner , Bernhard Hubert Geierstanger , Yunho Jin , Si Tuen Lee-Hoeflich , HongNgoc Thi Pham , Siew Ho Schleyer , Kathrin Tissot , Tetsuo Uno , Ben Wen
Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoetic stem cells in a patient in need thereof.
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Patent Agency Ranking
公开(公告)号：US20230270876A1
公开(公告)日：2023-08-31
申请号：US18178886
申请日：2023-03-06
Applicant: Novartis AG
Inventor： Bernhard Hubert Geierstanger , Weijia Ou , Tetsuo Uno
CPC classification number: A61K47/6817 , C07K16/32 , A61K47/6855 , A61K47/6871 , A61K47/6803 , C07K16/2863
Abstract: The present invention provides specific sites for modifying antibodies or antibody fragments by replacing at least one native amino acid in the constant region of a parental antibody or antibody fragment with cysteine, which can be used as a site of attachment for a payload or linker-payload combination.
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公开(公告)号：US11357864B2
公开(公告)日：2022-06-14
申请号：US16470897
申请日：2017-12-19
Applicant: NOVARTIS AG
Inventor： Ben Wen , Anthony E. Boitano , Matthew Burger , Susan E. Cellitti , Michael P. Cooke , Catrin Finner , Bernhard Hubert Geierstanger , Yunho Jin , Si Tuen Lee-Hoeflich , HongNgoc Thi Pham , Siew Ho Schleyer , Kathrin Tissot , Tetsuo Uno
Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.
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公开(公告)号：US20180155281A1
公开(公告)日：2018-06-07
申请号：US15822930
申请日：2017-11-27
Applicant: NOVARTIS AG
Inventor： Bernhard Hubert Geierstanger , Jan Grunewald , Weijia OU , Shifeng Pan , Tetsuo Uno , Yongqin Wan , Xing Wang
IPC: C07D207/09 , C07D401/12 , A61K47/68 , C07K16/32 , C07D403/12 , C07D403/14 , C07D413/12
CPC classification number: C07D207/09 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6855 , C07D401/12 , C07D403/12 , C07D403/14 , C07D413/12 , C07K5/0205 , C07K16/32
Abstract: Disclosed herein are novel compounds of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
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公开(公告)号：US11833215B2
公开(公告)日：2023-12-05
申请号：US16893359
申请日：2020-06-04
Applicant: Novartis AG
Inventor： Tinya Abrams , Steven Bruce Cohen , Dylan Daniel , Catrin Finner , Bernhard Hubert Geierstanger , Thomas Huber , William Mallet , Matthew John Meyer , Weijia Ou , Siew Ho Schleyer , Kathrin Ulrike Tissot-Daguette
CPC classification number: A61K47/6803 , A61K39/39558 , A61K47/6849 , A61K49/00 , A61K51/103 , A61K51/1093 , A61P35/02 , C07K16/2803 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/77 , C07K2317/92
Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
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公开(公告)号：US11634497B2
公开(公告)日：2023-04-25
申请号：US16482173
申请日：2018-02-01
Applicant: NOVARTIS AG
Inventor： Steven Bender , Tracy Charlton , Anna Galkin , Bernhard Hubert Geierstanger , Scott Martin Glaser , Shailaja Kasibhatla , Mark Knuth , Sabine Rottmann , Sarah Rue , Glen Spraggon , Tetsuo Uno
Abstract: This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.
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