- 专利标题： Lipid prodrugs of rapamycin and its analogs and uses thereof
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申请号： US16955084申请日： 2018-12-19
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公开(公告)号： US11608345B1公开(公告)日： 2023-03-21
- 发明人: Daniel Kenneth Bonner , Sifei Han , Luojuan Hu , Ketki Karanam , Christopher John Porter , Tim Quach , Rishab R. Shyam , Jamie Simpson , Natalie Trevaskis
- 申请人： PureTech LYT, Inc. , Monash University
- 申请人地址： US MA Boston; AU Clayton
- 专利权人： PureTech LYT, Inc.,Monash University
- 当前专利权人： PureTech LYT, Inc.,Monash University
- 当前专利权人地址： US MA Boston; AU Clayton
- 代理机构： Womble Bond Dickinson (US) LLP
- 代理商 Danielle L. Herritt
- 国际申请： PCT/US2018/066580 WO 20181219
- 国际公布： WO2019/126374 WO 20190627
- 主分类号： C07D498/18
- IPC分类号： C07D498/18 ; A61P37/06
摘要：
The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
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