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公开(公告)号：US11304954B2
公开(公告)日：2022-04-19
申请号：US16955162
申请日：2018-12-19
发明人： Daniel Kenneth Bonner , Ketki Karanam , Sifei Han , Luojuan Hu , Christopher John Hamilton Porter , Tim Quach , Rishab R. Shyam , Jamie Simpson , Natalie Trevaskis
IPC分类号： C07D413/12 , A61K31/5377 , A61K47/54 , A61P37/06
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
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公开(公告)号：US11938137B2
公开(公告)日：2024-03-26
申请号：US17586515
申请日：2022-01-27
发明人： Daniel Kenneth Bonner , Ketki Karanam , Sifei Han , Luojuan Hu , Christopher John Hamilton Porter , Tim Quach , Rishab R. Shyam , Jamie Simpson , Natalie Trevaskis
IPC分类号： A61K31/5377 , A61K47/54 , A61P37/06 , C07D413/12
CPC分类号： A61K31/5377 , A61K47/542 , A61P37/06 , C07D413/12
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
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公开(公告)号：US20220001015A1
公开(公告)日：2022-01-06
申请号：US16642794
申请日：2018-08-29
发明人： Daniel Kenneth Bonner , Ketki Karanam , James T. Mutamba , Rishab R. Shyam , Jamie Simpson , Sifei Han , Luojuan Hu , Christopher John Hamilton Porter , Tim Quach , Natalie Trevaskis
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof.
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公开(公告)号：US11608345B1
公开(公告)日：2023-03-21
申请号：US16955084
申请日：2018-12-19
发明人： Daniel Kenneth Bonner , Sifei Han , Luojuan Hu , Ketki Karanam , Christopher John Porter , Tim Quach , Rishab R. Shyam , Jamie Simpson , Natalie Trevaskis
IPC分类号： C07D498/18 , A61P37/06
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
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公开(公告)号：US11883497B2
公开(公告)日：2024-01-30
申请号：US16642794
申请日：2018-08-29
发明人： Daniel Kenneth Bonner , Ketki Karanam , James T. Mutamba , Rishab R. Shyam , Jamie Simpson , Sifei Han , Luojuan Hu , Christopher John Hamilton Porter , Tim Quach , Natalie Trevaskis
CPC分类号： A61K47/543 , A61K45/06
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof.
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公开(公告)号：US20240207411A1
公开(公告)日：2024-06-27
申请号：US18425761
申请日：2024-01-29
发明人： Daniel Kenneth Bonner , Ketki Karanam , James Tendai Mutamba , Rishab R. Shyam , Jamie Simpson , Sifei Han , Luojuan Hu , Christopher John Hamilton Porter , Tim Quach , Natalie Trevaskis
CPC分类号： A61K47/543 , A61K45/06
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof.
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公开(公告)号：US20220143038A1
公开(公告)日：2022-05-12
申请号：US17586515
申请日：2022-01-27
发明人： Daniel Kenneth Bonner , Ketki Karanam , Sifei Han , Luojuan Hu , Christopher John Hamilton Porter , Tim Quach , Rishab R. Shyam , Jamie Simpson , Natalie Trevaskis
IPC分类号： A61K31/5377 , A61K47/54 , A61P37/06 , C07D413/12
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
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