- 专利标题: Tumor-targeted agonistic CD28 antigen binding molecules
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申请号: US16721272申请日: 2019-12-19
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公开(公告)号: US11608376B2公开(公告)日: 2023-03-21
- 发明人: Guy Georges , Thomas Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Johannes Sam , Pablo Umaña , Jenny Thom , Stephan Gasser , Jean-Baptiste Vallier , Tanja Fauti
- 申请人: Hoffmann-La Roche Inc.
- 申请人地址: US NJ Little Falls
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: US NJ Little Falls
- 代理商 Yan Qi
- 优先权: EP18215121 20181221,EP19187709 20190723,EP19196006 20190906
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; C07K16/30 ; C07K16/32 ; C07K16/40 ; A61P35/00 ; A61K39/00
摘要:
The present invention relates to tumor targeted bispecific agonistic antigen binding molecules characterized by monovalent binding to CD28, methods for their production, pharmaceutical compositions containing these antibodies, and methods of using the same.
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