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公开(公告)号：US20210054021A1
公开(公告)日：2021-02-25
申请号：US16943067
申请日：2020-07-30
发明人： Laura Deak Codarri , Stefan Dengl , Jens Fischer , Thomas Hofer , Laurent Lariviere , Ekkehard Moessner , Stefan Seeber , Pablo Umana , Anne-Claire Zagdoun
摘要： The invention relates autonomous VH domains (aVH) with cysteines in positions 52a and 71 or in positions 33 and 52 in order to stabilize the autonomous VH domains. Said cysteines are capable of forming a disulfide bond and/or form a disulfide bond under suitable conditions. The invention further relates to aVH libraries.
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公开(公告)号：US20220213199A1
公开(公告)日：2022-07-07
申请号：US17644525
申请日：2021-12-15
发明人： Alexander Bujotzek , Alejandro Carpy Gutierrez Cirlos , Anne Freimoser-Grundschober , Carina Hage , Thomas Hofer , Silke Kirchner , Meher Majety , Ekkehard Moessner , Christiane Neumann , Christian Spick , Georg Tiefenthaler , Thomas Weindl
摘要： The present invention relates antibodies that bind to human HLA-G, multispecific antibodies thereof, their preparation, formulations and methods of using the same.
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公开(公告)号：US11180571B2
公开(公告)日：2021-11-23
申请号：US16587606
申请日：2019-09-30
发明人： Thomas Hofer , Maximiliane Koenig , Ekkehard Moessner , Jens Niewoehner , Tina Weinzierl , Laurent Lariviere
摘要： The present invention generally relates to antibodies that bind to STEAP-1, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
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公开(公告)号：US20170029529A1
公开(公告)日：2017-02-02
申请号：US15186098
申请日：2016-06-17
发明人： Rebecca Croasdale , Lydia Jasmin Duerner , Guy Georges , Thomas Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Samuel Moser , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Claudio Sustmann , Pablo Umana
IPC分类号： C07K16/32
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to bispecific HER2 antibodies, novel HER2 antibody variants, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及双特异性HER2抗体，新型HER2抗体变体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US11608376B2
公开(公告)日：2023-03-21
申请号：US16721272
申请日：2019-12-19
发明人： Guy Georges , Thomas Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Johannes Sam , Pablo Umaña , Jenny Thom , Stephan Gasser , Jean-Baptiste Vallier , Tanja Fauti
摘要： The present invention relates to tumor targeted bispecific agonistic antigen binding molecules characterized by monovalent binding to CD28, methods for their production, pharmaceutical compositions containing these antibodies, and methods of using the same.
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公开(公告)号：US11591397B2
公开(公告)日：2023-02-28
申请号：US17474980
申请日：2021-09-14
发明人： Anne Freimoser-Grundschober , Thomas Hofer , Ralf Hosse , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umaña , Inja Waldhauer , Wolfgang Richter , Alexander Knaupp , Halina Trochanowska
摘要： The present invention generally relates to antibodies that bind to CD3, including multi specific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
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公开(公告)号：US20220267464A1
公开(公告)日：2022-08-25
申请号：US17644903
申请日：2021-12-17
发明人： Claudia Ferrara Koller , Thomas Hofer , Christian Klein , Ekkehard Moessner , Christina Claus , Ralf Hosse , Bianca Scherer , Pablo Umana
IPC分类号： C07K16/30 , A61P35/00 , C07K14/705
摘要： The invention relates to new humanized CEA antibodies and to CEA targeting 4-1BBL trimer-containing antigen binding molecules comprising these CEA antibodies as well as their use in the treatment of cancer.
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公开(公告)号：US20200317774A1
公开(公告)日：2020-10-08
申请号：US16689880
申请日：2019-11-20
发明人： Thomas Hofer , Claudia Ferrara Koller , Ekkehard Moessner , Mi He
摘要： The present invention relates to antibodies against human CD19 (anti-human CD19 antibodies), methods for their production, pharmaceutical compositions containing these antibodies, and methods of using the same.
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公开(公告)号：US20200291131A1
公开(公告)日：2020-09-17
申请号：US16744697
申请日：2020-01-16
发明人： Rebecca Croasdale-Wood , Lydia Jasmin Hanisch , Guy Georges , Thomas Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Samuel Moser , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Claudio Sustmann , Pablo Umana
IPC分类号： C07K16/32
摘要： The present invention relates to bispecific HER2 antibodies, novel HER2 antibody variants, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US10584178B2
公开(公告)日：2020-03-10
申请号：US15186098
申请日：2016-06-17
发明人： Rebecca Croasdale-Wood , Lydia Jasmin Hanisch , Guy Georges , Thomas Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Samuel Moser , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Claudio Sustmann , Pablo Umana
摘要： The present invention relates to bispecific HER2 antibodies, novel HER2 antibody variants, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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