Invention Grant
- Patent Title: BCMA chimeric antigen receptors and uses thereof
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Application No.: US16439495Application Date: 2019-06-12
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Publication No.: US11608382B2Publication Date: 2023-03-21
- Inventor: Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agency: K&L Gates LLP
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61P35/00 ; A61K35/17 ; C07K14/725 ; C07K14/705 ; C12N5/0783 ; A61K38/00
Abstract:
The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
Public/Granted literature
- US20190382500A1 BCMA CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF Public/Granted day:2019-12-19
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