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公开(公告)号：US11939389B2
公开(公告)日：2024-03-26
申请号：US18170969
申请日：2023-02-17
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , A61K35/17 , A61P35/00 , C07K14/705 , C07K14/725 , C12N5/0783 , A61K38/00
CPC classification number: C07K16/2878 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70578 , C12N5/0636 , A61K38/00 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/76 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/33
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号：US20230183368A1
公开(公告)日：2023-06-15
申请号：US18170969
申请日：2023-02-17
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , A61P35/00 , A61K35/17 , C07K14/725 , C07K14/705 , C12N5/0783
CPC classification number: C07K16/2878 , A61P35/00 , A61K35/17 , C07K14/7051 , C07K14/70578 , C12N5/0636 , A61K38/00
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号：US11608382B2
公开(公告)日：2023-03-21
申请号：US16439495
申请日：2019-06-12
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , A61P35/00 , A61K35/17 , C07K14/725 , C07K14/705 , C12N5/0783 , A61K38/00
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号：US11952428B2
公开(公告)日：2024-04-09
申请号：US18170941
申请日：2023-02-17
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , A61K35/17 , A61P35/00 , C07K14/705 , C07K14/725 , C12N5/0783 , A61K38/00
CPC classification number: C07K16/2878 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70578 , C12N5/0636 , A61K38/00 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/76 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/33
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号：US20230416390A1
公开(公告)日：2023-12-28
申请号：US18184860
申请日：2023-03-16
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , A61P35/00 , A61K35/17 , C07K14/725 , C07K14/705 , C12N5/0783
CPC classification number: C07K16/2878 , A61P35/00 , A61K35/17 , C07K14/7051 , C07K14/70578 , C12N5/0636 , A61K38/00
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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Patent Agency Ranking
公开(公告)号：US20230250179A1
公开(公告)日：2023-08-10
申请号：US18170941
申请日：2023-02-17
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , A61P35/00 , A61K35/17 , C07K14/725 , C07K14/705 , C12N5/0783
CPC classification number: C07K16/2878 , A61P35/00 , A61K35/17 , C07K14/7051 , C07K14/70578 , C12N5/0636 , A61K38/00
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号：US20190382500A1
公开(公告)日：2019-12-19
申请号：US16439495
申请日：2019-06-12
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , C07K14/725 , C07K14/705 , C12N5/0783 , A61P35/00 , A61K35/17
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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8.发明授权公开(公告)号：US09982046B2
公开(公告)日：2018-05-29
申请号：US15346026
申请日：2016-11-08
Applicant: NOVARTIS AG
Inventor： Kurt Alex Heldwein , Igor Splawski , Jennifer Brogdon , Joshua Goldstein , William Dole , John Trauger , Chonghui Zhang
IPC: A61P9/08 , A61P9/04 , A61P9/10 , A61P9/12 , A61K39/395 , C07K16/28 , A61K9/00 , A61K45/06 , C07K14/47 , A61K39/00
CPC classification number: C07K16/28 , A61K9/0019 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , C07K14/4726 , C07K16/2851 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to monoclonal antibodies binding to human lectin-like oxidized LDL (low density lipoprotein) receptor 1 (hereinafter, sometimes referred to as “LOX-1”), and pharmaceutical compositions and methods of treatment comprising the same.
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公开(公告)号：US20220364055A1
公开(公告)日：2022-11-17
申请号：US17271430
申请日：2019-08-30
Applicant: Novartis AG
Inventor： Louise Treanor , Michael R. Greene , Jennifer Brogdon , Boris Engels , Glenn Dranoff , Olja Kodrasi , Hyungwook Lim , Akash Sohoni , Elizabeth Dorothy Pratico , Anniesha Hack , Aida Abujoub , Tony Fleming , Lu Huang , Connie Hong , John Blankenship , Brian Holmberg , Chonghui Zhang , Dexiu Bu , Andrew Price , Xu Zhu , Andrew Stein , Attilio Bondanza
IPC: C12N5/0783 , A61K35/17 , A61K31/519 , A61K38/20 , C07K16/28 , C07K14/705
Abstract: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.
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公开(公告)号：US20210220404A1
公开(公告)日：2021-07-22
申请号：US17104983
申请日：2020-11-25
Applicant: Michael R. Greene , Novartis AG
Inventor： Aida Abujoub , John Blankenship , Attilio Bondanza , Jennifer Brogdon , Dexiu Bu , Serena De Vita , Glenn Dranoff , Boris Engels , Tony Fleming , Brian Walter Granda , Michael R. Greene , Carla Patricia Guimaraes , Anniesha Hack , Brian Holmberg , Connie Hong , Lu Huang , Olja Kodrasi , Joni Waiee Lam , Hyungwook Lim , Elizabeth Dorothy Pratico , Andrew Price , Akash Sohoni , Andrew Marc Stein , Louise Treanor , Chonghui Zhang , Xu Zhu
IPC: A61K35/17 , C07K16/28 , A61P35/00 , A61K45/06 , A61K39/395 , C07K14/705 , A61K38/17 , C12N5/0783 , C07K14/725
Abstract: The invention provides immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions and methods thereof.
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