Invention Grant
- Patent Title: Universal histidine-tag binding compounds and methods of use thereof as fluorescent probes and sensors
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Application No.: US16783524Application Date: 2020-02-06
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Publication No.: US11639929B2Publication Date: 2023-05-02
- Inventor: David Margulies , Leila Motiei , Naama Lahav
- Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
- Applicant Address: IL Rehovot
- Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
- Current Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
- Current Assignee Address: IL Rehovot
- Agency: Pearl Cohen Zedek Latzer Baratz LLP
- Agent Mark S. Cohen
- Main IPC: C07D249/04
- IPC: C07D249/04 ; G01N33/533 ; G01N33/68 ; G01N33/58

Abstract:
This invention is directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further provides a system comprising recombinant cells decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying the cells and methods for using thereof.
Public/Granted literature
- US20200256857A1 UNIVERSAL HISTIDINE-TAG BINDING COMPOUNDS AND METHODS OF USE THEREOF AS FLUORESCENT PROBES AND SENSORS Public/Granted day:2020-08-13
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