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公开(公告)号：US10557853B2
公开(公告)日：2020-02-11
申请号：US15640545
申请日：2017-07-02
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： David Margulies , Leila Motiei , Linor Unger
IPC: C07D417/06 , G01N33/58 , C07D417/14 , C07K7/06 , C09K11/06 , G01N33/573 , G01N33/574
Abstract: The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.
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Patent Agency Ranking
公开(公告)号：US11639929B2
公开(公告)日：2023-05-02
申请号：US16783524
申请日：2020-02-06
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： David Margulies , Leila Motiei , Naama Lahav
IPC: C07D249/04 , G01N33/533 , G01N33/68 , G01N33/58
Abstract: This invention is directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further provides a system comprising recombinant cells decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying the cells and methods for using thereof.
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公开(公告)号：US20150232485A1
公开(公告)日：2015-08-20
申请号：US14414916
申请日：2013-07-16
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： David Margulies , Bhimsen Rout
CPC classification number: C07F5/025 , C07D211/60 , C09B62/44 , G01J3/4406 , G01N33/582 , G01N2400/00 , G01N2458/30 , G01N2800/042 , G01N2800/065 , G01N2800/067 , G01N2800/285
Abstract: The present invention is directed to a multi-sensor array compound including at least three chromophores, at least one receptor and an anchor. Contacting the compound of this invention with an analyte (such as carbohydrate) forms a complex with unique optical signature. The unique optical signature allows differentiating between carbohydrates, diagnosing diseases associated with the carbohydrate, and encoding information in an encoding system.
Abstract translation: 本发明涉及包含至少三个发色团，至少一个受体和锚的多传感器阵列化合物。 将本发明化合物与分析物（例如碳水化合物）接触形成具有独特光学特征的复合物。 独特的光学特征允许区分碳水化合物，诊断与碳水化合物相关的疾病，以及编码系统中的编码信息。
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4.发明授权公开(公告)号：US10557852B2
公开(公告)日：2020-02-11
申请号：US15307011
申请日：2015-04-28
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： David Margulies , Leila Motiei , Naama Mankovski , Yael Nissinkorn
Abstract: This invention is directed to monomolecular sensors, comprising a selective binder, a non-selective binder and a fluorophore, which can track changes that occur on the surface of labeled proteins. This invention is further directed to the use of such sensors for identifying binding partners of specific proteins. This invention is further directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins.
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公开(公告)号：US10281459B2
公开(公告)日：2019-05-07
申请号：US14754785
申请日：2015-06-30
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： David Margulies , Leila Motiei , Zohar Pode
IPC: C07K7/06 , G01N33/58 , G01N33/53 , C07D417/06 , C07D417/14 , C07F9/6541 , G01N33/574 , G01N33/573 , C09K11/06
Abstract: The present invention is directed to fluorescent protein biosensors based on oligonucleotide cross reactive sensor arrays including a selective and a non-selective protein surface binding domain for protein detection. Interaction of different protein isoforms with the sensors of this invention yields a unique optical signature for each protein. The unique optical signature allows differentiating between closely related protein isoforms and diagnosing diseases and disorders associated with the proteins also in biofluids.
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公开(公告)号：US09696310B2
公开(公告)日：2017-07-04
申请号：US14738894
申请日：2015-06-14
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： David Margulies , Leila Motiei , Linor Unger
IPC: C07D417/14 , G01N33/573 , C07D417/06 , C09K11/06 , G01N33/58 , C07F9/6541 , C07K7/06 , G01N33/574
CPC classification number: G01N33/573 , C07D417/06 , C07D417/14 , C07F9/6541 , C07K7/06 , C09K11/06 , C09K2211/1029 , C09K2211/1037 , G01N33/574 , G01N33/582 , G01N2333/91177 , G01N2333/918 , G01N2333/96494
Abstract: The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.
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