Invention Grant
- Patent Title: Calcium-chelating peptides derived from EF-hand calcium-binding motif
-
Application No.: US16759975Application Date: 2018-11-02
-
Publication No.: US11643449B2Publication Date: 2023-05-09
- Inventor: Xavier Nicol , Oriol Ros Torres
- Applicant: SORBONNE UNIVERSITÉ , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
- Applicant Address: FR Paris
- Assignee: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)
- Current Assignee: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)
- Current Assignee Address: FR Paris
- Agency: Christensen O'Connor Johnson Kindness PLLC
- Priority: EP 306514 2017.11.02
- International Application: PCT/EP2018/080032 2018.11.02
- International Announcement: WO2019/086617A 2019.05.09
- Date entered country: 2020-04-28
- Main IPC: C07K14/47
- IPC: C07K14/47 ; A61K38/00

Abstract:
The disclosure pertains to the field of molecular means capable of binding calcium, in particular peptides which are calcium chelators, appropriate for use in vitro or in vivo and preferably capable of targeting specific cellular compartments. Polypeptide comprising a first calcium-binding domain, a peptide linker and a second calcium binding domain, wherein the first and second binding domains are linked through the peptide linker, and wherein: the first calcium-binding domain and the second calcium binding domain each comprise at least one calcium-binding site derived from a EF-hand motif; and, the first calcium-binding domain and the second calcium binding domain differ in at least one calcium-binding site.
Public/Granted literature
- US20210179682A1 CALCIUM-CHELATING PEPTIDES DERIVED FROM EF-HAND CALCIUM-BINDING MOTIF Public/Granted day:2021-06-17
Information query