-
公开(公告)号：US20240417673A1
公开(公告)日：2024-12-19
申请号：US18700200
申请日：2022-10-13
Applicant: PARIS SCIENCES ET LETTRES , ÉCOLE NORMALE SUPÉRIEURE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SORBONNE UNIVERSITÉ , UNIVERSITÉ PARIS CITÉ
Inventor： Abdou Rachid THIAM , Alexandre SANTINHO , Vincent FAUGERAS
Abstract: A method based on the combination of a particular osmotic swelling, an adapted and controlled plasma membrane lysis and removal, to produce the giant extracellular organelles vesicles, and use of the giant extracellular organelles vesicles to screen the activity of proteins or exogenous molecules, the method includes: contacting the cells during 0.5 to 30 minutes with an hypotonic aqueous medium with an osmolarity ranging from 0.1 to 100 mOsm/L; applying a membrane tension on cells ranging from 10−3 to 5 mN/m during 10−4 to 100 seconds; and collecting the giant extracellular organelle vesicles into the hypotonic aqueous medium.
-
公开(公告)号：US12138111B2
公开(公告)日：2024-11-12
申请号：US17763259
申请日：2020-09-25
Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITÉ PARIS CITÉ , SORBONNE UNIVERSITÉ , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
Inventor： Mathieu Pernot , Thomas Deffieux , Mickael Tanter , Clément Papadacci
Abstract: Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method, which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.
-
3.发明申请公开(公告)号：US20240371526A1
公开(公告)日：2024-11-07
申请号：US18688493
申请日：2022-09-02
Applicant: ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) , ICM (INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SORBONNE UNIVERSITÉ
Inventor： Aurélie HANIN , Vincent NAVARRO , Mario CHAVEZ , Sophie DEMERET
Abstract: The invention relates to the field of patient's care and describes method and systems, for prediction of mortality, functional outcome and recovery after status epilepticus, based on machine classifiers and logistic regression functions, and using biological markers and variables easily obtainable in intensive care units.
-
公开(公告)号：US12133767B2
公开(公告)日：2024-11-05
申请号：US17293681
申请日：2019-11-14
Inventor： Bertrand Duplat , Quentin Francois , Sinan Haliyo , Régis Marchiano , Stéphane Regnier
Abstract: This system for real-time localization of a millimetric or submillimetric object, such as a microrobot, in a viscoelastic medium, in particular in an organ of a subject such as a brain, a liver or a pancreas, includes: at least one bubble configured to be attached to said object, the or each bubble having a hermetic envelope filled with a gas; at least one ultrasound transducer configured to emit initial ultrasound signals and to detect deflected ultrasound signals deflected at the surface of the bubble(s); a processing unit in communication with the ultrasound transducers and configured to generate localization data of the object from localization data of the bubble(s) based on the deflected ultrasound signals detected by the ultrasound transducers.
-
公开(公告)号：US20240229154A9
公开(公告)日：2024-07-11
申请号：US18546028
申请日：2022-02-11
Applicant: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE , SORBONNE UNIVERSITÉ , UNIVERSITE PARIS CITE
Inventor： Lubka ROUMENINA , Marie DAUGAN , Margot REVEL , Isabelle CREMER , Catherine SAUTES-FRIDMAN , Wolf Herman FRIDMAN
IPC: C12Q1/6886 , C12Q1/6874 , G01N33/574
CPC classification number: C12Q1/6886 , C12Q1/6874 , G01N33/57496 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N2333/4716
Abstract: Complement components form a plasma innate immune cascade but could also serve as multitasking proteins, as they have functions beyond this system. Here, we show that complement FH is locally expressed by multiple types of human tumors. We provide a paradigm shift for the impact of FH on cancer progression, showing a previously unrecognized, intracellular function of FH outside the complement cascade, while the canonical, complement-regulatory function had no effect. Int-FH served as a driver of the proliferation and migration of ccRCC and lung ADK cells but not of normal cells or lung SCC cells. The presence of int-FH staining in tumor cells indicated poor prognosis for ccRCC and lung ADK. Thus, the invention relates to a method for predicting the survival time of a patient suffering from a cancer, comprising i) determining in a sample obtained from the patient the expression level of int-FH ii) comparing the expression level determined at step i) with its predetermined reference value and iii) providing a prognosis when the expression level determined at step i) is modulated compared to its predetermined reference value.
-
Patent Agency Ranking
公开(公告)号：US12021192B2
公开(公告)日：2024-06-25
申请号：US17252981
申请日：2019-06-18
Inventor： Jean-Marie Tarascon , Guochun Yan
IPC: H01M10/0567 , H01M4/133 , H01M4/1393 , H01M4/62 , H01M10/054 , H01M10/0568 , H01M10/0569
CPC classification number: H01M10/0567 , H01M4/133 , H01M4/1393 , H01M4/622 , H01M10/054 , H01M10/0568 , H01M10/0569 , H01M2300/0037 , H01M2300/0051
Abstract: An electrolyte composition includes at least a sodium salt dissolved in at least one solvent and a combination of additives. The solvent is any of ethylene carbonate, dimethyl carbonate, ethyl methyl carbonate, diethyl carbonate, propylene carbonate, ethyl acetate, ethyl propionate, methyl propionate, 4-fluorotoluene, 1,1,2,2-tetrafluoroethyl 2,2,3,3-tetrafluoropropyl ether, di-fluoro ethylene carbonate, ethyl difluoroacetate, or mixtures of the foregoing. The combination of additives includes at least sodium difluoro(oxalato)borate (NaODFB) and tris(trimethylsilyl)phosphite (TMSPi).
-
公开(公告)号：US20240178451A1
公开(公告)日：2024-05-30
申请号：US18551717
申请日：2022-03-22
Inventor： Sathiya Mariyappan , Jean-Marie Tarascon , Hussein Hijazi
IPC: H01M10/0567 , H01M10/052 , H01M10/0568 , H01M10/0569
CPC classification number: H01M10/0567 , H01M10/052 , H01M10/0568 , H01M10/0569 , H01M2300/0037
Abstract: An electrolyte composition including at least one sodium salt dissolved in a solvent and a combination of additives, wherein: the solvent includes at least one compound selected from the group consisting of ethylene carbonate, dimethyl carbonate, ethyl methyl carbonate, diethyl carbonate, propylene carbonate, a carboxylate ester such as methyl acetate, ethyl acetate, ethyl propionate and methyl propionate, 4-fluorotoluene, 1,1,2,2-tetrafluoroethyl 2,2,3,3-tetrafluoropropyl ether, di-fluoro ethylene carbonate, ethyl difluoroacetate and diglyme, and the combination of additives comprises at least tris(trimethylsilyl)phosphite (TMSPi) and succinonitrile (SN).
-
公开(公告)号：US20240132974A1
公开(公告)日：2024-04-25
申请号：US18546028
申请日：2022-02-11
Applicant: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE , SORBONNE UNIVERSITÉ , UNIVERSITE PARIS CITE
Inventor： Lubka ROUMENINA , Marie DAUGAN , Margot REVEL , Isabelle CREMER , Catherine SAUTES-FRIDMAN , Wolf Herman FRIDMAN
IPC: C12Q1/6886 , C12Q1/6874 , G01N33/574
CPC classification number: C12Q1/6886 , C12Q1/6874 , G01N33/57496 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N2333/4716
Abstract: Complement components form a plasma innate immune cascade but could also serve as multitasking proteins, as they have functions beyond this system. Here, we show that complement FH is locally expressed by multiple types of human tumors. We provide a paradigm shift for the impact of FH on cancer progression, showing a previously unrecognized, intracellular function of FH outside the complement cascade, while the canonical, complement-regulatory function had no effect. Int-FH served as a driver of the proliferation and migration of ccRCC and lung ADK cells but not of normal cells or lung SCC cells. The presence of int-FH staining in tumor cells indicated poor prognosis for ccRCC and lung ADK. Thus, the invention relates to a method for predicting the survival time of a patient suffering from a cancer, comprising i) determining in a sample obtained from the patient the expression level of int-FH ii) comparing the expression level determined at step i) with its predetermined reference value and iii) providing a prognosis when the expression level determined at step i) is modulated compared to its predetermined reference value.
-
公开(公告)号：US11962037B2
公开(公告)日：2024-04-16
申请号：US17154771
申请日：2021-01-21
Applicant: SYMBIO , COLLEGE DE FRANCE , Sorbonne Université , Centre national de la recherche scientifique
Inventor： Christophe Vacquier , Nathalia Rovira , Christophe Baverel , Christel Laberty-Robert , Laura Coustan , Clément Sanchez
IPC: H01M50/497 , H01M50/403 , H01M50/426 , H01M50/449
CPC classification number: H01M50/497 , H01M50/403 , H01M50/426 , H01M50/449
Abstract: The present application relates to a proton exchange membrane for fuel cell, said membrane having self-regenerating properties, to cells comprising said membranes, and to the manufacturing method thereof via electrospinning.
-
公开(公告)号：US20230266322A1
公开(公告)日：2023-08-24
申请号：US18003999
申请日：2021-06-28
Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP) , SORBONNE UNIVERSITÉ , Université Paris Cité
Inventor： Franck PAGES , Jérôme GALON , Guy ZEITOUN , Amos KIRILOVSKY
IPC: G01N33/574
CPC classification number: G01N33/574 , G01N2800/54
Abstract: The inventors assessed in locally advanced rectal cancer whether a diagnostic biopsy-adapted Immunoscore (ISB) could predict response to neoadjuvant treatment (nT) and better define patients eligible to a postoperative adjuvant therapy. The inventors showed that ISB was an independent parameter, more informative than pre- (P
-
-
-
-
-
-
-
-
-
Search Results
172
records
(took 0.025 seconds)
