- 专利标题： ALK2 inhibitors and methods for inhibiting BMP signaling
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申请号： US17340589申请日： 2021-06-07
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公开(公告)号： US11654147B2公开(公告)日： 2023-05-23
- 发明人: Paul B. Yu , Wenwei Huang , Philip Edward Sanderson , Jian-Kang Jiang , Khalida Shamim , Wei Zheng , Xiuli Huang , Gregory Tawa , Arthur Lee , Asaf Alimardanov , Junfeng Huang
- 申请人： The Brigham and Women's Hospital, Inc. , The United States of America, as Represented by the Secretary, Department of Health and Human Services
- 申请人地址： US MA Boston
- 专利权人： The Brigham and Women's Hospital, Inc.,The United States of America, as Represented by the Secretary, Dept. of Health and Human Services
- 当前专利权人： The Brigham and Women's Hospital, Inc.,The United States of America, as Represented by the Secretary, Dept. of Health and Human Services
- 当前专利权人地址： US MA Boston; US MD Bethesda
- 代理机构： Foley Hoag LLP
- 代理商 David P. Halstead
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; A61P19/08 ; A61K31/5377 ; A61K31/551 ; A61K31/675 ; A61K45/06 ; C07D487/04 ; C07D519/00 ; C07F9/6561
摘要：
The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjögren's syndrome, or diffuse intrinsic pontine glioma (DIPG).
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