Facilitating a time-division multiplexing pattern-based solution for a dual-subscriber identity module with a single radio in advanced networks (e.g., 5G, 6G, and beyond) is provided herein. Operations of a method can comprise obtaining, by a network device comprising a processor, multiple time-division multiplexing patterns applicable to a mobile device. The multiple time-division multiplexing patterns indicate respective repeating patterns of an on state and an off state of a defined identity of the mobile device. The method also can comprise facilitating, by the network device, a transmission, to the mobile device, of information indicative of the multiple time-division multiplexing patterns. In an example, the mobile device can be configured to operate with at least two subscriber identity modules.