![Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof](/docs/US/2023-06-13/US11674163B2/abs.jpg.600x600.jpg)
- 专利标题： Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
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申请号： US17474777申请日： 2021-09-14
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公开(公告)号： US11674163B2公开(公告)日： 2023-06-13
- 发明人: Antonio Garrido Montalban , Daniel J. Buzard , John A. DeMattei , Tawfik Gharbaoui , Stephen R. Johannsen , Ashwin M. Krishnan , Young Mi Kuhlman , You-An Ma , Michael John Martinelli , Suzanne Michiko Sato , Dipanjan Sengupta
- 申请人： Arena Pharmaceuticals, Inc.
- 申请人地址： US CA San Diego
- 专利权人： Arena Pharmaceuticals, Inc.
- 当前专利权人： Arena Pharmaceuticals, Inc.
- 当前专利权人地址： US NY New York
- 代理商 Feng Shao
- 分案原申请号： US13575458
- 主分类号： C12P17/10
- IPC分类号： C12P17/10 ; C07D209/80 ; C07D209/94 ; C07C17/278 ; C07D209/88 ; C07D295/155
![Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof](/abs-image/US/2023/06/13/US11674163B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to processes and intermediates useful in the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of Formula (Ia) and salts thereof, an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development and atherosclerosis).
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