Invention Grant
- Patent Title: Stabilized receptor polypeptides and uses thereof
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Application No.: US16388561Application Date: 2019-04-18
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Publication No.: US11685770B2Publication Date: 2023-06-27
- Inventor: Jeonghoon Sun , Lei-Ting Tony Tam , Mark Leo Michaels , Thomas Charles Boone , Rohini Deshpande , Yue-Sheng Li , Huiquan Han
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Lisa E. Alexander
- The original application number of the division: US12626375 2009.11.25
- Main IPC: C07K14/495
- IPC: C07K14/495 ; C07K14/71 ; A61K38/00
Abstract:
The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.
Public/Granted literature
- US20200283504A9 STABILIZED RECEPTOR POLYPEPTIDES AND USES THEREOF Public/Granted day:2020-09-10
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