公开(公告)号：US20170183391A9

公开(公告)日：2017-06-29

申请号：US15004375

申请日：2016-01-22

Applicant: Amgen Inc.

Inventor： Jeonghoon Sun ,  Lei-Ting Tony Tam ,  Mark Leo Michaels ,  Thomas Charles Boone ,  Rohini Deshpande ,  Yue-Sheng Li ,  Huiquan Han

IPC: C07K14/71

CPC classification number: C07K14/71 ,  A61K38/00 ,  C07K14/495

Abstract: The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.

公开(公告)号：US20150175687A1

公开(公告)日：2015-06-25

申请号：US14528959

申请日：2014-10-30

Applicant: AMGEN INC.

Inventor： Huiquan Han ,  Hosung Min ,  Thomas Charles Boone

IPC: C07K16/22 ,  G01N33/74

CPC classification number: C07K16/22 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/00 ,  C07K14/475 ,  C07K2317/21 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/35 ,  C12N2710/14143 ,  G01N33/567 ,  G01N33/74 ,  G01N2333/475

Abstract: The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therapeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and metabolic disorders including diabetes and obesity.

Abstract translation: 本发明提供了包含能够结合肌生成抑制素并抑制其活性的肽的结合剂。 在一个实施方案中，结合剂包含至少一种与至少一种载体如聚合物或Fc结构域直接或间接连接的肌肉生长抑制素结合肽。 本发明的粘合剂在施用于动物时产生瘦肌肉质量的降低，并且脂肪与肌肉的比例降低。 含有本发明结合剂的治疗组合物可用于治疗肌肉消瘦疾病和代谢紊乱，包括糖尿病和肥胖症。

公开(公告)号：US10189912B2

公开(公告)日：2019-01-29

申请号：US15405233

申请日：2017-01-12

Applicant: AMGEN INC.

Inventor： Kenneth W. Walker ,  Yue-Sheng Li ,  Thomas Charles Boone ,  George Doellgast ,  HoSung Min ,  Jane Talvenheimo ,  Taruna Arora ,  Frederick W. Jacobsen

IPC: C07K16/44 ,  A61K39/395 ,  C07K16/00 ,  C07K16/18 ,  C07K14/435 ,  C07K14/575 ,  C07K14/605 ,  C07K16/24 ,  C07K14/66 ,  A61K47/68

Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.

公开(公告)号：US09562108B2

公开(公告)日：2017-02-07

申请号：US14285579

申请日：2014-05-22

Applicant: AMGEN INC.

Inventor： Kenneth W. Walker ,  Yue-Sheng Li ,  Thomas Charles Boone ,  HoSung Min ,  Jane Talvenheimo ,  Taruna Arora ,  Frederick W. Jacobsen

IPC: C07K16/44 ,  A61K39/395 ,  C07K16/00 ,  C07K16/18 ,  C07K14/435 ,  C07K14/575 ,  C07K14/605 ,  C07K16/24

CPC classification number: C07K16/44 ,  A61K39/39591 ,  A61K47/6817 ,  A61K47/6843 ,  C07K14/43504 ,  C07K14/575 ,  C07K14/605 ,  C07K14/66 ,  C07K16/00 ,  C07K16/18 ,  C07K16/248 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/55

Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.

Abstract translation: 公开了分离的抗原结合蛋白，例如但不限于抗体或抗体片段。 还公开了包含抗原结合蛋白，编码它的分离的核酸，载体，宿主细胞和用于制备它的方法中的杂交瘤的药物组合物和药物。 在一些实施方案中，抗原结合蛋白包含与其结合的1-24个药理活性化学部分，例如药理学活性多肽。

公开(公告)号：US20140286953A1

公开(公告)日：2014-09-25

申请号：US14103351

申请日：2013-12-11

Applicant: Amgen Inc.

Inventor： Barbra Sasu ,  Mitsuru Haniu ,  Thomas Charles Boone ,  Xiao-juan Bi ,  Grace Ki Jeong Lee ,  Tara Arvedson ,  Aaron George Winters ,  Keegan Cooke ,  Jackie Z. Sheng

IPC: C07K16/26 ,  A61K38/18 ,  G01N33/74 ,  A61K39/395

CPC classification number: C07K16/26 ,  A61K38/1816 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/575 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  C12N15/1136 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  G01N33/74 ,  A61K2300/00

Abstract: The invention relates to purified, correctly folded hepcidin, antibodies that bind hepcidin, and methods of making and using such materials. Also provide are methods of treated hepcidin-related disorders.

Abstract translation: 本发明涉及纯化的，正确折叠的铁调素，结合铁调素的抗体，以及制备和使用这些材料的方法。 还提供了治疗的铁调素相关病症的方法。

公开(公告)号：US11685770B2

公开(公告)日：2023-06-27

申请号：US16388561

申请日：2019-04-18

Applicant: AMGEN INC.

Inventor： Jeonghoon Sun ,  Lei-Ting Tony Tam ,  Mark Leo Michaels ,  Thomas Charles Boone ,  Rohini Deshpande ,  Yue-Sheng Li ,  Huiquan Han

IPC: C07K14/495 ,  C07K14/71 ,  A61K38/00

CPC classification number: C07K14/71 ,  C07K14/495 ,  A61K38/00

Abstract: The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.

公开(公告)号：US09562107B2

公开(公告)日：2017-02-07

申请号：US14285576

申请日：2014-05-22

Applicant: AMGEN INC.

Inventor： Kenneth W. Walker ,  Yue-Sheng Li ,  Thomas Charles Boone ,  George Doellgast ,  HoSung Min ,  Jane Talvenheimo ,  Taruna Arora ,  Frederick W. Jacobsen

IPC: C07K16/44 ,  A61K39/395 ,  C07K16/00 ,  C07K16/18 ,  C07K14/435 ,  C07K14/575 ,  C07K14/605 ,  C07K16/24

CPC classification number: C07K16/44 ,  A61K39/39591 ,  A61K47/6817 ,  A61K47/6843 ,  C07K14/43504 ,  C07K14/575 ,  C07K14/605 ,  C07K14/66 ,  C07K16/00 ,  C07K16/18 ,  C07K16/248 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/55

Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.

公开(公告)号：US20160137718A1

公开(公告)日：2016-05-19

申请号：US15004375

申请日：2016-01-22

Applicant: Amgen Inc.

Inventor： Jeonghoon Sun ,  Lei-Ting Tony Tam ,  Mark Leo Michaels ,  Thomas Charles Boone ,  Rohini Deshpande ,  Yue-Sheng Li ,  Huiquan Han

IPC: C07K14/71

CPC classification number: C07K14/71 ,  A61K38/00 ,  C07K14/495

Abstract: The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.

Abstract translation: 本发明提供稳定的活化素IIB受体多肽和能够结合并抑制活化素A，肌生成抑制素或GDF-11的活性的蛋白质。 本发明还提供能够产生稳定的多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了治疗肌肉消瘦疾病和代谢紊乱的组合物和方法。

公开(公告)号：US20130336992A1

公开(公告)日：2013-12-19

申请号：US13975748

申请日：2013-08-26

Applicant: AMGEN INC.

Inventor： Thomas Charles Boone ,  Jonathan Daniel Oliner ,  Eunkyung Lee

IPC: C07K16/28

CPC classification number: C07K16/22 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/2863 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: Disclosed are specific binding agents, such as fully human antibodies, that bind to angiopoietin 1 and/or angiopoietin-2. Also disclosed are heavy chain fragments, light chain fragments, and CDRs of the antibodies, as well as methods of making and using the antibodies.

Abstract translation: 公开了结合血管生成素1和/或血管生成素-2的特异性结合剂，例如完全人抗体。 还公开了抗体的重链片段，轻链片段和CDR，以及制备和使用抗体的方法。

公开(公告)号：US10336820B2

公开(公告)日：2019-07-02

申请号：US15367955

申请日：2016-12-02

Applicant: AMGEN INC.

Inventor： Thomas Charles Boone ,  Jonathan Daniel Oliner ,  Eunkyung Lee

IPC: A61K39/00 ,  C07K16/22 ,  C07K16/28

Abstract: Disclosed are specific binding agents, such as fully human antibodies, that bind to angiopoietin 1 and/or angiopoietin-2. Also disclosed are heavy chain fragments, light chain fragments, and CDRs of the antibodies, as well as methods of making and using the antibodies.