- Patent Title: Lensfree method for imaging biological samples in three dimensions
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Application No.: US17128092Application Date: 2020-12-19
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Publication No.: US11687031B2Publication Date: 2023-06-27
- Inventor: Zhenxiang Luo , Abdulkadir Yurt , Dries Braeken , Liesbet Lagae , Richard Stahl
- Applicant: IMEC VZW , Katholieke Universiteit Leuven
- Applicant Address: BE Leuven
- Assignee: IMEC VZW,KATHOLIEKE UNIVERSITEIT LEUVEN
- Current Assignee: IMEC VZW,KATHOLIEKE UNIVERSITEIT LEUVEN
- Current Assignee Address: BE Leuven; BE Leuven
- Agency: Moser Taboada
- Priority: EP 218967 2019.12.20
- Main IPC: G03H1/04
- IPC: G03H1/04 ; G03H1/00 ; H04N13/254 ; G02B21/06 ; G02B21/36

Abstract:
A method for three-dimensional imaging of a sample (302) comprises: receiving (102) interference patterns (208) acquired using light-detecting elements (212), wherein each interference pattern (208) is formed by scattered light from the sample (302) and non-scattered light from a light source (206; 306), wherein the interference patterns (208) are acquired using different angles between the sample (302) and the light source (206; 306); performing digital holographic reconstruction applying an iterative algorithm to change a three-dimensional scattering potential of the sample (302) to improve a difference between the received interference patterns (208) and predicted interference patterns based on the three-dimensional scattering potential; wherein the iterative algorithm reduces a sum of a data fidelity term and a non-differentiable regularization term and wherein the iterative algorithm includes a forward-backward splitting method alternating between forward gradient descent (108) on the data fidelity term and backward gradient descent (110) on the regularization term.
Public/Granted literature
- US20210191316A1 LENSFREE METHOD FOR IMAGING BIOLOGICAL SAMPLES IN THREE DIMENSIONS Public/Granted day:2021-06-24
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