Methods, computer program products, and/or systems are provided that perform the following operations: in a data replication environment, analyzing a database workload to generate a knowledge base of information related to compression; dividing a transfer data stream into different segments based, at least in part, on the knowledge base; obtaining candidate compression types for the transfer data stream based, at least in part, on the knowledge base; assigning respective compression types of the candidate compression types to the different segments; generating compressed segments based, at least in part, on the respective compression types assigned to the different segments; and providing the compressed segments to a replication target.