A method for guiding a sales strategy of loquat fruits by evaluating and predicting quality of the loquat fruits is provided. The method slices and stains an equatorial plane of an loquat fruit and calculates a lignified cell density P of the equatorial plane of the loquat fruit, so as to guide a current price of a batch of loquat fruits. The current price of the loquat fruits increases as P decreases. The method analyzes a growth stage of the lignified cells and predicts a quality change trend value T of the batch of loquat fruits, so as to guide a storage strategy based on T. The loquat fruits are suitable for storage and transportation when T is high, and the loquat fruits need to be sold as soon as possible when T is low.