- 专利标题： Production bacterial cells and use thereof in production methods
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申请号： US17742671申请日： 2022-05-12
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公开(公告)号： US11697802B2公开(公告)日： 2023-07-11
- 发明人: Jesus Fernandez Rodriguez , Antoine Decrulle , Aymeric Leveau , Ines Canadas Blasco , Aurélie Mathieu , Thibault Carlier
- 申请人： Eligo Bioscience
- 申请人地址： FR Paris
- 专利权人： Eligo Bioscience
- 当前专利权人： Eligo Bioscience
- 当前专利权人地址： FR Paris
- 代理机构： Arrigo, Lee, Guttman & Mouta-Bellum LLP
- 主分类号： C12N7/00
- IPC分类号： C12N7/00 ; C12N1/20 ; C12N15/74 ; C12N15/70
摘要：
The present invention concerns a production bacterial cell for producing phage particles or phage-derived delivery vehicles, said production bacterial cell stably comprising at least one phage structural gene(s) and at least one phage DNA packaging gene(s), said phage structural gene(s) and phage DNA packaging gene(s) being derived from a first type of bacteriophage,
wherein the expression of at least one of said phage structural gene(s) and/or at least one of said phage DNA packaging gene(s) in said production bacterial cell is controlled by at least one induction mechanism, and
wherein said production bacterial cell is from a bacterial species or strain different from the bacterial species or strain from which said first type of bacteriophage comes and/or that said first type of bacteriophage targets.
wherein the expression of at least one of said phage structural gene(s) and/or at least one of said phage DNA packaging gene(s) in said production bacterial cell is controlled by at least one induction mechanism, and
wherein said production bacterial cell is from a bacterial species or strain different from the bacterial species or strain from which said first type of bacteriophage comes and/or that said first type of bacteriophage targets.
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