A surgical instrument comprising a shaft, an end effector, a housing, a drive assembly, and a manually-driven actuator is disclosed. The end effector comprises a first jaw and a second jaw rotatable relative to the first jaw between an open position and a clamped position. The housing comprises a rotary input movable by a motor. The drive assembly is operably engaged with the rotary input. The drive assembly is movable by the motor in a motorized mode of operation to transition the second jaw toward the clamped position. The drive assembly is movable in a non-motorized mode of operation by the manually-driven actuator to permit a transition of the second jaw toward the open position to release tissue between the first jaw and the second jaw.