Invention Grant
- Patent Title: Chemical compounds
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Application No.: US17227819Application Date: 2021-04-12
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Publication No.: US11702405B2Publication Date: 2023-07-18
- Inventor: Ariamala Gopalsamy , Shawn Cabral , Agustin Casimiro-Garcia , Ming Zhu Chen , Chulho Choi , Robert Lee Dow , Olugbeminiyi Omezia Fadeyi , David Hepworth , Jayasankar Jasti , Lyn Howard Jones , Arjun Venkat Narayanan , Mihir Dineshkumar Parikh , David Walter Piotrowski , Lee Richard Roberts , Ralph Pelton Robinson, Jr. , Hatice Gizem Yayla
- Applicant: Pfizer Inc.
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agent John A. Wichtowski
- Main IPC: C07D401/14
- IPC: C07D401/14 ; A61P7/06 ; C07D471/04 ; A61K45/06

Abstract:
The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.
More particularly the invention relates to HbS modulators of formula (I)
or tautomers thereof, or pharmaceutically acceptable salts of said modulators or tautomers thereof, wherein X, Y, R2 and R3 are as defined in the description.
HbS modulators are potentially useful in the treatment of a wide range of disorders, including sickle cell disease (SCD).
More particularly the invention relates to HbS modulators of formula (I)
or tautomers thereof, or pharmaceutically acceptable salts of said modulators or tautomers thereof, wherein X, Y, R2 and R3 are as defined in the description.
HbS modulators are potentially useful in the treatment of a wide range of disorders, including sickle cell disease (SCD).
Public/Granted literature
- US20220348555A1 Chemical Compounds Public/Granted day:2022-11-03
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