- 专利标题： Cell-based assay for determining activity in the retinoblastoma pathway
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申请号： US17502217申请日： 2021-10-15
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公开(公告)号： US11702666B2公开(公告)日： 2023-07-18
- 发明人: Tatyana Naryshkina
- 申请人： Medical Diagnostic Laboratories, LLC
- 申请人地址： US NJ Hamilton
- 专利权人： Medical Diagnostic Laboratories, LLC
- 当前专利权人： Medical Diagnostic Laboratories, LLC
- 当前专利权人地址： US NJ Hamilton
- 代理商 Arnold Braun; Jessica Dowling
- 主分类号： C12N15/79
- IPC分类号： C12N15/79 ; C12N9/02 ; G01N33/50 ; C12Q1/48 ; C12N9/12
摘要：
Disclosed are methods of determining activity of CDK4 and CDK6 variants upon exposure to CDK inhibitors, methods for determining activity of a Rb variant, methods for determining the activity of a p16 variant in a cell, and methods for determining the sensitivity of a CDK4 variant or a CDK6 variant to p16 in a cell. Stable cell lines for determining activity of CDK4 variants, CDK6 variants, Rb variants, and p16 variants are also disclosed.
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