Methods, systems, and computer storage media storing instructions for managing processing system efficiency. One of the methods includes obtaining data splitting a plurality of general-purpose processing units in a processing system into a high-priority domain and a low-priority domain, wherein the general-purpose processing units in the high-priority domain are assigned to perform one or more tasks comprising one or more high-priority tasks, and the general-purpose processing units in the low-priority domain are assigned to perform one or more low-priority tasks; and during runtime of the processing system, obtaining memory usage measurements that characterize usage of system memory by the high-priority domain and the low-priority domain; and adjusting, based on the memory usage measurements, a configuration of (i) the high-priority domain, (ii) the low-priority domain, or (iii) both to adjust utilization of the system memory by the general-purpose processing units.