Novel techniques are described for gateway routing and/or processing of multi-tenant Internet-of-Things (IoT) device data streams. For example, a single IoT routing gateway can be used to route device data streams from IoT devices of multiple customers according to rule-based routing tiers. The routing tiers define routing protocols, including which communication technologies to use for transmission of the device data streams over a cloud network to remote servers. In some cases, the routing tiers further define processing protocols to facilitate rule-based edge processing (and/or remote processing) of some or all device data streams. Some routing tiers can define a primary and one or more secondary solution for routing and/or processing, according to customer-defined rules. In some cases, the routing tiers further enable rule-based control of interconnectivity among IoT devices.