- 专利标题： Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
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申请号： US17168574申请日： 2021-02-05
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公开(公告)号： US11708347B2公开(公告)日： 2023-07-25
- 发明人: Pravin L. Kotian , Yarlagadda S. Babu , Weihe Zhang , Peng-Cheng Lu , Minwan Wu , Wei Lv , Trung Xuan Nguyen , Zhao Dang , Venkat R. Chintareddy , V. Satish Kumar , Krishnan Raman
- 申请人： BioCryst Pharmaceuticals, Inc.
- 申请人地址： US NC Durham
- 专利权人： BioCryst Pharmaceuticals, Inc.
- 当前专利权人： BioCryst Pharmaceuticals, Inc.
- 当前专利权人地址： US NC Durham
- 代理机构： Foley Hoag LLP
- 代理商 Dana M. Gordon; Laura A. Wzorek
- 分案原申请号： US16511642 2019.07.15
- 主分类号： C07D401/10
- IPC分类号： C07D401/10 ; C07D209/12 ; C07D261/20 ; C07D307/80 ; C07D333/64 ; C07D401/12 ; C07D405/10
摘要：
Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.
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