公开(公告)号：US12103907B2

公开(公告)日：2024-10-01

申请号：US18239892

申请日：2023-08-30

Applicant: ARCUS BIOSCIENCES, INC.

Inventor： Joel Worley Beatty ,  Samuel Lawrie Drew ,  Matthew Epplin ,  Jeremy Thomas Andre Fournier ,  Balint Gal ,  Tezcan Guney ,  Karl T. Haelsig ,  Clayton Hardman ,  Steven Donald Jacob ,  Jenna Leigh Jeffrey ,  Jaroslaw Kalisiak ,  Kenneth Victor Lawson ,  Manmohan Reddy Leleti ,  Erick Allen Lindsey ,  Artur Karenovich Mailyan ,  Debashis Mandal ,  Guillaume Mata ,  Hyunyoung Moon ,  Jay Patrick Powers ,  Brandon Reid Rosen ,  Yongli Su ,  Anh Thu Tran ,  Zhang Wang ,  Xuelei Yan ,  Kai Yu

IPC: C07C317/32 ,  A61K31/10 ,  A61K31/277 ,  A61K31/343 ,  A61K31/353 ,  A61K31/365 ,  A61K31/381 ,  A61K31/404 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4174 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/423 ,  A61K31/426 ,  A61K31/428 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/5025 ,  A61K31/505 ,  A61K31/519 ,  A61K31/538 ,  A61K39/395 ,  A61K45/06 ,  C07C255/53 ,  C07C317/22 ,  C07C317/36 ,  C07D209/34 ,  C07D211/86 ,  C07D213/57 ,  C07D213/71 ,  C07D213/73 ,  C07D213/74 ,  C07D213/84 ,  C07D215/48 ,  C07D217/04 ,  C07D231/12 ,  C07D231/56 ,  C07D233/64 ,  C07D237/20 ,  C07D239/42 ,  C07D241/12 ,  C07D249/06 ,  C07D249/08 ,  C07D263/32 ,  C07D263/57 ,  C07D265/36 ,  C07D277/30 ,  C07D277/56 ,  C07D277/64 ,  C07D307/83 ,  C07D311/22 ,  C07D333/64 ,  C07D401/04 ,  C07D401/10 ,  C07D409/10 ,  C07D413/10 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07C317/32 ,  A61K31/10 ,  A61K31/277 ,  A61K31/343 ,  A61K31/353 ,  A61K31/365 ,  A61K31/381 ,  A61K31/404 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4174 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/423 ,  A61K31/426 ,  A61K31/428 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/5025 ,  A61K31/505 ,  A61K31/519 ,  A61K31/538 ,  A61K39/3955 ,  A61K45/06 ,  C07C255/53 ,  C07C317/22 ,  C07C317/36 ,  C07D209/34 ,  C07D211/86 ,  C07D213/57 ,  C07D213/71 ,  C07D213/73 ,  C07D213/74 ,  C07D213/84 ,  C07D215/48 ,  C07D217/04 ,  C07D231/12 ,  C07D231/56 ,  C07D233/64 ,  C07D237/20 ,  C07D239/42 ,  C07D241/12 ,  C07D249/06 ,  C07D249/08 ,  C07D263/32 ,  C07D263/57 ,  C07D265/36 ,  C07D277/30 ,  C07D277/56 ,  C07D277/64 ,  C07D307/83 ,  C07D311/22 ,  C07D333/64 ,  C07D401/04 ,  C07D401/10 ,  C07D409/10 ,  C07D413/10 ,  C07D471/04 ,  C07D487/04 ,  C07C2602/08 ,  C07C2602/10

Abstract: Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.

公开(公告)号：US20230147360A1

公开(公告)日：2023-05-11

申请号：US17832388

申请日：2022-06-03

Applicant: Genzyme Corporation

Inventor： Junkai Liao ,  Mark Munson ,  Zhongli Gao ,  Gregory Hurlbut ,  Hans Peter Nestler ,  Ingrid Mechin ,  Martin Smrcina ,  Ronghua Li ,  Ryan Hartung ,  William Bock ,  Bertrand Vivet ,  Andrew Scholte

IPC: C07D333/54 ,  C07D417/12 ,  C07D333/64 ,  C07D417/04 ,  C07D277/64 ,  A61K45/06

CPC classification number: C07D333/54 ,  C07D417/12 ,  C07D333/64 ,  C07D417/04 ,  C07D277/64 ,  A61K45/06

Abstract: The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

公开(公告)号：US11407712B2

公开(公告)日：2022-08-09

申请号：US17205273

申请日：2021-03-18

Applicant: ARCUS BIOSCIENCES, INC.

Inventor： Joel Worley Beatty ,  Samuel Lawrie Drew ,  Matthew Epplin ,  Jeremy Thomas Andre Fournier ,  Balint Gal ,  Tezcan Guney ,  Karl T. Haelsig ,  Clayton Hardman ,  Steven Donald Jacob ,  Jenna Leigh Jeffrey ,  Jaroslaw Kalisiak ,  Kenneth Victor Lawson ,  Manmohan Reddy Leleti ,  Erick Allen Lindsey ,  Artur Karenovich Mailyan ,  Debashis Mandal ,  Guillaume Mata ,  Hyunyoung Moon ,  Jay Patrick Powers ,  Brandon Reid Rosen ,  Yongli Su ,  Anh Thu Tran ,  Zhang Wang ,  Xuelei Yan ,  Kai Yu

IPC: C07C317/32 ,  A61K31/10 ,  A61K31/277 ,  A61K31/343 ,  A61K31/353 ,  A61K31/365 ,  A61K31/381 ,  A61K31/404 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4174 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/423 ,  A61K31/426 ,  A61K31/428 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/5025 ,  A61K31/505 ,  A61K31/519 ,  A61K31/538 ,  A61K39/395 ,  A61K45/06 ,  C07C255/53 ,  C07C317/22 ,  C07C317/36 ,  C07D209/34 ,  C07D211/86 ,  C07D213/57 ,  C07D213/71 ,  C07D213/73 ,  C07D213/74 ,  C07D213/84 ,  C07D215/48 ,  C07D217/04 ,  C07D231/12 ,  C07D231/56 ,  C07D233/64 ,  C07D237/20 ,  C07D239/42 ,  C07D241/12 ,  C07D249/06 ,  C07D249/08 ,  C07D263/32 ,  C07D263/57 ,  C07D265/36 ,  C07D277/30 ,  C07D277/56 ,  C07D277/64 ,  C07D307/83 ,  C07D311/22 ,  C07D333/64 ,  C07D401/04 ,  C07D401/10 ,  C07D409/10 ,  C07D413/10 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.

公开(公告)号：US11370774B2

公开(公告)日：2022-06-28

申请号：US17202965

申请日：2021-03-16

Applicant: BioCryst Pharmaceuticals, Inc.

Inventor： Pravin L. Kotian ,  Yarlagadda S. Babu ,  Weihe Zhang ,  Peng-Cheng Lu ,  Minwan Wu ,  Wei Lv ,  Trung Xuan Nguyen ,  Zhao Dang ,  Venkat R. Chintareddy ,  V. Satish Kumar ,  Krishnan Raman

IPC: C07D401/10 ,  C07D209/12 ,  C07D261/20 ,  C07D307/80 ,  C07D333/64 ,  C07D401/12 ,  C07D405/10

Abstract: Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.

公开(公告)号：US20210221786A1

公开(公告)日：2021-07-22

申请号：US17202965

申请日：2021-03-16

Applicant: BioCryst Pharmaceuticals, Inc.

Inventor： Pravin L. Kotian ,  Yarlagadda S. Babu ,  Weihe Zhang ,  Peng-Cheng Lu ,  Minwan Wu ,  Wei Lv ,  Trung Xuan Nguyen ,  Zhao Dang ,  Venkat R. Chintareddy ,  V. Satish Kumar ,  Krishnan Raman

IPC: C07D401/10 ,  C07D209/12 ,  C07D261/20 ,  C07D307/80 ,  C07D333/64 ,  C07D401/12 ,  C07D405/10

Abstract: Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.

公开(公告)号：US20210171554A1

公开(公告)日：2021-06-10

申请号：US17176962

申请日：2021-02-16

Applicant: G1 Therapeutics, Inc.

Inventor： Jay Copeland Strum

IPC: C07F9/6558 ,  C07D409/12 ,  C07D333/64 ,  C07F9/6553

Abstract: This invention is a benzothiophene estrogen receptor modulator or its pharmaceutically acceptable salt, N-oxide, isotopic derivative, or prodrug thereof or a pharmaceutically acceptable composition thereof to treat an estrogen-related medical disorder. The invention also includes a combination thereof with another active agent such as a CDK inhibitor, including a CDK4/6 inhibitor, to treat a disorder mediated by the estrogen receptor, as described in more detail herein.

公开(公告)号：US20200347032A1

公开(公告)日：2020-11-05

申请号：US16963794

申请日：2019-01-22

Applicant: Radius Pharmaceuticals, Inc.

Inventor： Chris Miller

IPC: C07D403/10 ,  C07D487/04 ,  C07D209/30 ,  C07D333/64 ,  C07D409/12 ,  C07D495/04 ,  A61P35/04

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：US20200299281A1

公开(公告)日：2020-09-24

申请号：US16088374

申请日：2017-03-27

Applicant: Novartis AG

Inventor： Fabrice Gallou ,  Michael PARMENTIER ,  Jianguang ZHOU ,  Pengfei GUO

IPC: C07D405/14 ,  C07D401/04 ,  C07D403/14 ,  C07C269/06 ,  C07D333/64 ,  C07C211/52 ,  C07D487/04 ,  C07D241/20

Abstract: The present invention is directed to reaction mixtures comprising a water-surfactant mixture and a co-solvent. This technology reduced the amount of organic solvents needed for performing chemical reactions. Furthermore, compared to reaction mixtures lacking the co-solvent, solvation of the reactants and products of the chemical reaction is greatly enhanced, leading to a significantly improved yield, purity, reproducibility and robustness.

公开(公告)号：US10308871B2

公开(公告)日：2019-06-04

申请号：US15547063

申请日：2016-02-10

Applicant: JNC CORPORATION ,  JNC PETROCHEMICAL CORPORATION

Inventor： Tomohiro Yano

IPC: G02F1/1333 ,  C09K19/34 ,  C07D333/54 ,  C07D333/56 ,  C09K19/30 ,  C09K19/32 ,  C09K19/42 ,  G02F1/13 ,  C07D333/64 ,  C07D409/04 ,  C07D409/08 ,  C07D409/10 ,  C07D409/12 ,  C09K19/54 ,  C09K19/58

Abstract: Provided is a liquid crystal compound that has high stability to heat, light and so forth, a high clearing point, low minimum temperature of a liquid crystal phase, small viscosity, suitable optical anisotropy, large negative dielectric anisotropy, a suitable elastic constant and excellent compatibility with other liquid crystal compounds, a liquid crystal composition containing the compound and a liquid crystal display device including the composition.The compound is represented by formula (1). For example, R1 is alkyl having 1 to 10 carbons, alkoxy having 1 to 9 carbons or alkenyl having 2 to 10 carbons; R2 is alkyl having 1 to 10 carbons, alkoxy having 1 to 9 carbons or alkenyl having 3 to 10 carbons; ring A1 is 1,4-cyclohexylene or 1,4-phenylene; ring A2 is 1,4-cyclohexylene or 1,4-phenylene; Z1 and Z2 are a single bond; Z3 is —O— or a single bond; and L1 is F, CF3 or CF2H.

公开(公告)号：US10118910B2

公开(公告)日：2018-11-06

申请号：US15374966

申请日：2016-12-09

Applicant: The Board of Trustees of the University of Illinois

Inventor： Gregory R. Thatcher ,  Rui Xiong ,  Jiong Zhao ,  Debra A. Tonetti

IPC: C07D333/64 ,  C07D409/12 ,  C07D409/06

Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.