Embodiments of negative pressure wound therapy systems and methods are disclosed. In some embodiments, a wound therapy system includes a negative pressure source configured to provide negative pressure via a fluid flow path to a wound dressing, a first circuit board assembly including a first controller configured to control a wound therapy with the wound dressing by activation and deactivation of the negative pressure source, and a second circuit board assembly in communication with the first circuit board assembly, the second circuit board assembly separate from the first circuit board assembly. The second circuit board assembly can include a second controller configured to wirelessly communicate therapy data via a communication network, receive an executable command from an electronic device, and execute the executable command without providing the executable command to the first controller.